Impact of intensive dosing of mycophenolate on pancreas allograft survival
| Autor: | Glen Leverson, Jon S. Odorico, Jillian L. Descourouez, Nathan Menninga, Robert R. Redfield, Margaret R. Jorgenson |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Urology 030230 surgery Malignancy Mycophenolate Mycophenolic acid 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Humans Medicine Dosing Retrospective Studies Transplantation Kidney Antibiotics Antineoplastic business.industry Incidence (epidemiology) Graft Survival Mycophenolic Acid Allografts Prognosis medicine.disease Survival Rate surgical procedures operative medicine.anatomical_structure Etiology Female 030211 gastroenterology & hepatology Pancreas Transplantation business Pancreas Follow-Up Studies medicine.drug |
| Zdroj: | Clinical Transplantation. 32:e13293 |
| ISSN: | 0902-0063 |
| Popis: | Purpose To evaluate the effect of mycophenolate (mycophenolic acid, MPA) dose on pancreas allograft survival following simultaneous pancreas kidney (SPK) transplant. Methods This was an observational study of adult SPK recipients transplanted between 1/1/2002 and 6/30/2015. Recipients were divided into cohorts based on MPA dose at discharge: high dose (HD), 1000 mg three times daily mycophenolate mofetil (MMF) and standard dose (SD), 1000 mg twice daily MMF. Primary outcome was pancreas allograft survival. Secondary endpoints included kidney allograft survival, pancreas allograft rejection, infection, time to initial dose decrease, and patient survival (PS). Results In all, 453 patients met inclusion criteria: 324 in HD-MPA group and 129 in SD-MPA group. HD-MPA patients had higher rates of pancreas graft survival (P = .003). There were no differences in rates of pancreas allograft rejection (P = .8), kidney graft survival (P = .15), overall infection (P = .4), overall malignancy (P = .93), time to first dose reduction (P = .35), or patient survival (P = .3). In a multivariable analysis adjusted for differences between groups and known confounders, dosing group continued to significantly affect incidence of pancreas allograft failure (P = .02). Conclusions HD-MPA significantly impacted pancreas allograft survival in SPK recipients independent of graft rejection. Further studies are warranted to investigate the etiology of this finding and determine the optimal duration of HD-MPA associated with positive graft outcomes. |
| Databáze: | OpenAIRE |
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