Protecting-group-free synthesis of a dual CCK1/CCK2 receptor antagonist
| Autor: | Neelakandha S. Mani, Jing Liu, Hariharan Venkatesan, Xiaohu Deng, Anne E. Fitzgerald, Zachary S. Sales |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cck2 receptor
chemistry.chemical_classification Molecular Structure Chemistry Stereochemistry medicine.drug_class Carboxylic acid Organic Chemistry Antagonist Stereoisomerism Carboxamide Biochemistry Receptor Cholecystokinin B Receptor Cholecystokinin A Sulfonamide medicine Physical and Theoretical Chemistry Protecting group |
| Zdroj: | Organic & Biomolecular Chemistry. 9:2654 |
| ISSN: | 1477-0539 1477-0520 |
| DOI: | 10.1039/c0ob01004a |
| Popis: | In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe(2) mediated carboxamide formation, both in the presence of a carboxylic acid. Practical synthesis of an unnatural, chiral β-aryl-α-amino acid is also described. |
| Databáze: | OpenAIRE |
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