Augmenting effect of methionine-enkephalin on interleukin-6 production by cytokine-stimulated murine macrophages
| Autor: | K. Makowiecka, Belowski D, Zbigniew S. Herman, Jan Kowalski |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Lipopolysaccharides
Male endocrine system medicine.medical_specialty Cellular immunity Enkephalin Methionine medicine.medical_treatment Adipose tissue macrophages Macrophage-activating factor (+)-Naloxone Biology Proinflammatory cytokine Interferon-gamma Mice Cellular and Molecular Neuroscience Endocrinology Internal medicine Escherichia coli medicine Animals Macrophage Interleukin 6 Cells Cultured Interleukin-6 Endocrine and Autonomic Systems General Medicine Macrophage Activation Recombinant Proteins Mice Inbred C57BL Cytokine Neurology Macrophages Peritoneal biology.protein Interleukin-1 |
| Zdroj: | Neuropeptides. 34:187-192 |
| ISSN: | 0143-4179 |
| DOI: | 10.1054/npep.2000.0812 |
| Popis: | The effects of methionine-enkephalin on the production of interleukin-6 by activated peritoneal murine macrophages were studied. Macrophage were activated with interleukin-1beta or interferon-gamma in the presence or absence of graded concentrations of methionine-enkephalin. Methionine-enkephalin combined with interleukin-1beta or interferon-gamma caused an increase in IL-6 release from cultured macrophages. The opioid receptor antagonist naloxone did not change the stimulatory effect of methionine-enkephalin on IL-6 production by stimulated macrophages. Methionine-enkephalin added to the culture medium of resting macrophages increased IL-6 release from macrophages which were later induced with interleukin-1beta or interferon-gamma. The results of this study suggest that methionine-enkephalin can modulate the proinflammatory cytokine response by controlling, via non-opioid receptor mechanism, the production of IL-6. |
| Databáze: | OpenAIRE |
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