Antioxidant and free radical-scavenging enzymes in chronically ethanol-consuming rats: controversy over hepatic lipid peroxidation
| Autor: | G.D. Nadkarni, Nympha B. D'Souza |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Antioxidant Free Radicals medicine.medical_treatment Toxicology Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Internal medicine medicine Animals Pharmacology (medical) Liver Diseases Alcoholic Pharmacology chemistry.chemical_classification Glutathione Peroxidase Ethanol biology Superoxide Dismutase Glutathione peroxidase Rats Inbred Strains Catalase Rats Psychiatry and Mental health Alcoholism Enzyme Endocrinology chemistry Liver Toxicity biology.protein Lipid Peroxidation |
| Zdroj: | Drug and alcohol dependence. 22(1-2) |
| ISSN: | 0376-8716 |
| Popis: | In rats given ethanol 20% (v/v) in drinking water the hepatic antioxidant enzymes, Superoxide dismutase (SOD), catalase and glutathione peroxidase were assayed at the end of 4 and 10 months of ethanol consumption. Simultaneously hepatic lipid peroxidation was monitored. At 4 months SOD and catalase were unaffected, while glutathione peroxidase was decreased by 48%. By the end of 10 months SOD had declined by 16% and glutathione peroxidase activity increased by 49%, while catalase again remained stable. However, hepatic lipid peroxidation was not significantly affected throughout the study. The controversy in the literature over the conflicting results of hepatic lipid peroxidation in chronically ethanol-fed rats is discussed in the light of mode, dose, duration of ethanol consumption, nutritional status of the rat, and primacy of glutathione peroxidase. |
| Databáze: | OpenAIRE |
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