Spiral blurring correction with water–fat separation for magnetic resonance fingerprinting in the breast
| Autor: | Mariya Doneva, Peter Koken, Aaldert Jan Elevelt, Teresa Nolte, Volkmar Schulz, Christiane K. Kuhl, Nicolas Gross-Weege, Daniel Truhn |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Magnetic Resonance Spectroscopy genetic structures Breast imaging FOS: Physical sciences Inversion recovery Imaging phantom 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted medicine Humans Radiology Nuclear Medicine and imaging ddc:610 Small tumors Spiral Physics medicine.diagnostic_test Phantoms Imaging Water Magnetic resonance imaging Magnetic Resonance Imaging Physics - Medical Physics 3. Good health Spin echo Female Medical Physics (physics.med-ph) sense organs Algorithms 030217 neurology & neurosurgery Phase reconstruction Biomedical engineering |
| Zdroj: | Magnetic resonance in medicine 83(4), 1192-1207 (2020). doi:10.1002/mrm.27994 Magnetic Resonance in Medicine |
| ISSN: | 1522-2594 0740-3194 |
| Popis: | PURPOSE: Magnetic Resonance Fingerprinting (MRF) with spiral readout enables rapid quantification of tissue relaxation times. However, it is prone to blurring due to off-resonance effects. Hence, fat blurring into adjacent regions might prevent identification of small tumors by their quantitative T1 and T2 values. This study aims to correct for the blurring artifacts, thereby enabling fast quantitative mapping in the female breast. METHODS: The impact of fat blurring on spiral MRF results was first assessed by simulations. Then, MRF was combined with 3-point Dixon water-fat separation and spiral blurring correction based on conjugate phase reconstruction. The approach was assessed in phantom experiments and compared to Cartesian reference measurements, namely inversion recovery (IR), multi-echo spin echo (MESE) and Cartesian MRF, by normalized root mean square error (NRMSE) and standard deviation (STD) calculations. Feasibility is further demonstrated in-vivo for quantitative breast measurements of 6 healthy female volunteers, age range 24-31 years. RESULTS: In the phantom experiment, the blurring correction reduced the NRMSE per phantom vial on average from 16% to 8% for T1 and from 18% to 11% for T2 when comparing spiral MRF to IR/MESE sequences. When comparing to Cartesian MRF, the NRMSE reduced from 15% to 8% for T1 and from 12% to 7% for T2. Furthermore, STDs decreased. In-vivo, the blurring correction removed fat bias on T1/T2 from a rim of about 7-8 mm width adjacent to fatty structures. CONCLUSION: The blurring correction for spiral MRF yields improved quantitative maps in the presence of water and fat. Submitted to Magnetic Resonance in Medicine. 13 pages, 7 figures, 3 tables |
| Databáze: | OpenAIRE |
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