Combined drug design of potential Mycobacterium tuberculosis and HIV-1 inhibitors: 3’,4’-di-substituted -4'H-spiro[isothiochromene-3,5'-isoxazol]-4(1H)-one
| Autor: | Abdelali Kerbal, Brahim Bennani, B. Filali Baba, T. Ben Hadda, G. Al Houari, Abraham F. Jalbout, S. Öztürk Yıldırım, Mohammed Benazza, Gilles Demailly, Mostafa Mimouni, Mehmet Akkurt, M. Daoudi |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Drug
biology Chemistry Stereochemistry media_common.quotation_subject Organic Chemistry Human immunodeficiency virus (HIV) medicine.disease_cause biology.organism_classification In vitro Virus Mycobacterium tuberculosis lcsh:QD241-441 lcsh:Organic chemistry Mic values medicine Pharmacophore Bacteria media_common |
| Zdroj: | ARKIVOC, Vol 2007, Iss 16, Pp 19-40 (2007) |
| ISSN: | 1551-7012 1551-7004 |
| Popis: | We report herein the design and synthesis of 17 new spiroheterocycles 10-26, on the basis of two hypothetical pharmacophore structures designed to interact with both of Mycobacterium tuberculosis bacteria and HIV-1 virus. The in vitro biological evaluation of these compounds allowed us to point out seven new potential non-nucleoside hits, with MIC values in the range of 6.25 mu g/mL and two new potential anti-HIV-1 inhibitors. |
| Databáze: | OpenAIRE |
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