Molecular detection and genomic characterization of diverse hepaciviruses in African rodents
| Autor: | Bram Vrancken, Joëlle Goüy de Bellocq, Josef Bryja, Frederik Van de Perre, Philippe Lemey, Elke Wollants, Sylvestre Gambalemoke Mbalitini, Magda Bletsa, Jana Těšíková, Yonas Meheretu, Sophie Gryseels, Yiqiao Li, Sebastian Lequime, Oliver G. Pybus, Benjamin Dudu Akaibe, Marc Van Ranst, Jan Felix Drexler, Natalie Van Houtte, Herwig Leirs, Antonios Fikatas, Rhodes H. Makundi, Ine Boonen, Erik Verheyen, Anne Laudisoit |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Rodent Hepatitis C virus Hepacivirus Population HCV genotypes Cross-species transmission medicine.disease_cause 010603 evolutionary biology 01 natural sciences Microbiology Genome 03 medical and health sciences Hepatits C virus Virology biology.animal medicine AcademicSubjects/MED00860 rodent hepacivirus education Biology 030304 developmental biology 0303 health sciences education.field_of_study biology Host (biology) AcademicSubjects/SCI01130 AcademicSubjects/SCI02285 cross-species transmission biology.organism_classification recombination 3. Good health Evolutionary biology hepacivirus co-infection Human medicine Research Article |
| Zdroj: | Virus Evolution Virus evolution |
| ISSN: | 2057-1577 |
| Popis: | Hepatitis C virus (HCV; genus Hepacivirus) represents a major public health problem, infecting about three per cent of the human population. Because no animal reservoir carrying closely related hepaciviruses has been identified, the zoonotic origins of HCV still remain unresolved. Motivated by recent findings of divergent hepaciviruses in rodents and a plausible African origin of HCV genotypes, we have screened a large collection of small mammals samples from seven sub-Saharan African countries. Out of 4,303 samples screened, eighty were found positive for the presence of hepaciviruses in twenty-nine different host species. We, here, report fifty-six novel genomes that considerably increase the diversity of three divergent rodent hepacivirus lineages. Furthermore, we provide strong evidence for hepacivirus co-infections in rodents, which were exclusively found in four sampled species of brush-furred mice. We also detect evidence of recombination within specific host lineages. Our study expands the available hepacivirus genomic data and contributes insights into the relatively deep evolutionary history of these pathogens in rodents. Overall, our results emphasize the importance of rodents as a potential hepacivirus reservoir and as models for investigating HCV infection dynamics. ispartof: VIRUS EVOLUTION vol:7 issue:1 ispartof: location:England status: published |
| Databáze: | OpenAIRE |
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