Effect of anti-TNF and conventional synthetic disease-modifying anti-rheumatic drug treatment on work disability and clinical outcome in a multicentre observational cohort study of psoriatic arthritis
| Autor: | Neil McHugh, Amelia Jobling, SE Lane, Gavin Shaddick, Philip S. Helliwell, William Tillett, Annie Cooper, J. Packham, Lesley Kay, Paul Creamer, Ragai Shaban, Eleanor Korendowych, Ayman Askari, Jana James, Gavin Clunie, Matthew L. Thomas, Lyn Williamson |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Work Capacity Evaluation Efficiency Disease Antibodies Monoclonal Humanized Etanercept Anti-TNF Biological Factors 03 medical and health sciences Psoriatic arthritis 0302 clinical medicine Rheumatology Internal medicine medicine Humans Disabled Persons Pharmacology (medical) Prospective Studies 030212 general & internal medicine 030203 arthritis & rheumatology Medical treatment Tumor Necrosis Factor-alpha Work disability business.industry Anti rheumatic drugs Arthritis Psoriatic Adalimumab Antibodies Monoclonal Middle Aged Presenteeism medicine.disease Infliximab Occupational Diseases Treatment Outcome Unemployment Outcomes research Antirheumatic Agents csDMARDs Physical therapy Female business Cohort study |
| Zdroj: | Tillett, W, Shaddick, G, Jobling, A, Askari, A, Cooper, A, Creamer, P, Clunie, G, Helliwell, P S, James, J, Kay, L, Korendowych, E, Lane, S, Packham, J, Shaban, R, Thomas, M L, Williamson, L & McHugh, N 2017, ' Effect of anti-TNF and conventional synthetic disease-modifying anti-rheumatic drug treatment on work disability and clinical outcome in a multicentre observational cohort study of psoriatic arthritis ', Rheumatology (United Kingdom), vol. 56, no. 4, pp. 603-612 . https://doi.org/10.1093/rheumatology/kew433 Tillett, W, Shaddick, G, Jobling, A, Askari, A, Cooper, A, Creamer, P, Clunie, G, Helliwell, P S, James, J, Kay, L, Korendowych, E, Lane, S, Packham, J, Shaban, R, Thomas, M L, Williamson, L & McHugh, N 2017, ' Effect of anti-TNF and conventional synthetic disease-modifying anti-rheumatic drug treatment on work disability and clinical outcome in a multicentre observational cohort study of psoriatic arthritis ', Rheumatology, vol. 56, no. 4, pp. 603-612 . https://doi.org/10.1093/rheumatology/kew433 |
| DOI: | 10.1093/rheumatology/kew433 |
| Popis: | OBJECTIVE: To determine the effect of medical treatment on work disability in patients with active PsA in a real-world setting.METHODS: Four hundred patients with active PsA commencing or switching to anti-TNF or conventional synthetic DMARD (csDMARD) were recruited to a multicentre UK prospective observational cohort study. Work disability was measured using the work productivity and activity-specific health problem instrument and peripheral joint activity was measured with the disease activity in PsA composite measure.RESULTS: Four hundred patients were recruited, of whom 229 (57.25%) were working (of any age). Sixty-two patients of working age (24%) were unemployed. At 6 months there was a 10% improvement in presenteeism (P = 0.007) and a 15% improvement in work productivity (P = 0.001) among working patients commenced on csDMARDs (n = 164) vs a larger and more rapid 30% improvement in presenteeism (P < 0.001) and 40% improvement in work productivity (P < 0.001) among those commenced on anti-TNF therapy (n = 65). Clinical response was poor among patients commenced on a csDMARD (n = 272), with an 8.4 point improvement in disease activity in PsA (P < 0.001) vs those commenced on anti-TNF therapy (n = 121), who had a 36.8 point improvement (P < 0.001).CONCLUSION: We report significant and clinically meaningful improvements in both work disability and clinical outcomes after commencement of anti-TNF therapy in a real-world setting. Improvements in all outcomes among those commencing csDMARDs were slower and of a smaller magnitude. |
| Databáze: | OpenAIRE |
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