The effect of alcohol consumption in the treatment of nontuberculous mycobacteria
| Autor: | Rita Gaio, Maria Jacob, Ricardo M. P. da Silva, Raquel Duarte |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine medicine.medical_specialty Lung Neoplasms Alcohol Drinking Cystic Fibrosis Mycobacterium Infections Nontuberculous HIV Infections Comorbidity Disease Logistic regression Odds Pulmonary Disease Chronic Obstructive 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Aged Retrospective Studies Aged 80 and over lcsh:RC705-779 Portugal biology business.industry Incidence (epidemiology) Nontuberculous Mycobacteria Environmental Exposure lcsh:Diseases of the respiratory system Odds ratio Middle Aged biology.organism_classification Confidence interval Treatment Outcome 030228 respiratory system Female Nontuberculous mycobacteria business Alcohol consumption |
| Zdroj: | Pulmonology, Vol 26, Iss 4, Pp 249-252 (2020) |
| ISSN: | 2531-0437 |
| Popis: | Background: the incidence of nontuberculous mycobacteria (NTM) disease is increasing and its presentation and severity can vary. Treatment of NTM disease is long, requires multiple drugs and the overall outcome can be related to host factors. Aim: to identify the effect of the alcohol consumption on the treatment outcome, crude and adjusted for other host variables. Methods: a retrospective analysis of patients with NTM disease between 2003-2016 (data from the Portuguese National Epidemiological Surveillance Commission for TB). Logistic regression models assessed odds ratios (OR) with 95% confidence interval (CI) for an unsuccessful treatment outcome. Results: 610 patients were included, 540 (89%) had lung NTM disease. The average age was 58±18.2 years and 369 were male patients. Five hundred and seventeen (84.8%) patients finished treatment successfully (good outcome) and 93 (15.2%) died while in treatment (bad outcome). The crude OR for alcohol consumption was 3.48 (95% CI1.91-6.21 p Conclusion: after adjustment for potential risk factors, alcohol consumption was estimated to double the odds for an unsuccessful outcome. This underlines the need of close monitoring among patients with alcohol dependencies to improve treatment outcomes. |
| Databáze: | OpenAIRE |
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