A Case of IgG4-related Sclerosing Mesenteritis
| Autor: | Zeeshan Butt, Syed H Alam, Sonum Singh, Oleksandr Semeniuk, Irene J Tan, Gurdeep Singh Chhabra |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Abdominal pain
medicine.medical_specialty Pathology Exploratory laparotomy medicine.medical_treatment igg4-related disease abdominal mass Sclerosing mesenteritis Lymphoid hyperplasia 03 medical and health sciences 0302 clinical medicine Rheumatology medicine Internal Medicine Fat necrosis sclerosing mesenteritis mesenteric mass business.industry General Engineering Gastroenterology medicine.disease Abdominal mass 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Histopathology IgG4-related disease medicine.symptom business |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | A 60-year-old African-American male presented to the emergency department with abdominal pain and distention associated with decreased appetite and weight loss for several weeks. A computed tomography (CT) scan of the abdomen and pelvis showed an 8 cm mesenteric mass with surrounding stranding and poorly defined borders. The patient underwent exploratory laparotomy and complete resection of the mass since the frozen section could not give a definite diagnosis. Histopathology showed fibro-adipose tissue with lymphoid hyperplasia, vague nodular collections of foamy histiocytes with giant cell reaction, marked chronic inflammation, fat necrosis, and prominent sclerosis/fibrosis. Methenamine silver and acid-fast stains were negative for fungal and mycobacterial organisms respectively. Examination of tissue with immunohistostains showed increased immunoglobulin G4 (IgG4)-positive plasma cells. Other features observed were scattered areas of phlebitis, pockets of tissue eosinophilia, and focal storiform fibrosis leading to the diagnosis of IgG4-related sclerosing mesenteritis. The patient did not require steroids after the surgical resection and was disease free at six-month follow up. |
| Databáze: | OpenAIRE |
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