Seminal plasma homocysteine, folate and cobalamin in men with obstructive and non-obstructive azoospermia
| Autor: | Záková J, Igor Crha, Michal Pohanka, Jitka Melounová, Pavel Ventruba, Michaela Králíková, Rastislav Beharka, R. Husicka, Martin Huser |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Non obstructive azoospermia endocrine system medicine.medical_specialty Luminescence Homocysteine Semen urologic and male genital diseases Cobalamin Gastroenterology Statistics Nonparametric chemistry.chemical_compound Folic Acid Internal medicine polycyclic compounds Genetics medicine Humans Gonadal Physiology and Disease Chromatography High Pressure Liquid Genetics (clinical) Azoospermia urogenital system business.industry nutritional and metabolic diseases Obstetrics and Gynecology General Medicine medicine.disease Vitamin B 12 Endocrinology Reproductive Medicine chemistry Folic acid Plasma homocysteine business Developmental Biology |
| Zdroj: | Journal of Assisted Reproduction and Genetics. 27:533-538 |
| ISSN: | 1573-7330 1058-0468 |
| Popis: | The aim of this study was to analyze homocysteine, folate and cobalamin in men with normozoospermia, obstructive and non-obstructive azoospermia.Analysis of plasma and seminal plasma homocysteine, folate and cobalamin in 72 azoospermic and 62 normozoospermic men. Evaluation of the azoospermic patient included testicular biopsy, endocrine, urological and ultrasound examination.Homocysteine (1.2 μmol/l) and cobalamin (322.05 pmol/l) concentrations (median values) in seminal plasma were significantly lower (p 0.001) in men with azoospermia than in men with normozoospermia (2.5 μmol/l and 579.0 pmol/l). Folate and cobalamin concentrations were significantly higher in obstructive than in non-obstructive azoospermia. Significant correlations were determined between testis volume and seminal plasma homocysteine in azoospermic men.Lower concentrations of homocysteine and cobalamin (but not folate) were found in azoospermic seminal plasma than normozoospermic. Folate and cobalamin were higher in seminal plasma from obstructive azoospermia than in non-obstructive azoospermia patients. |
| Databáze: | OpenAIRE |
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