Metformin decreases lung cancer risk in diabetic patients in a dose-dependent manner
| Autor: | Yu-Ting Shen, Pi-Yu Chang, Chau-Chyun Sheu, Herng-Chia Chiu, Ming-Ju Tsai, Chih-Jen Yang, Ya-Ting Kung, Ming-Shyan Huang |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Risk Pulmonary and Respiratory Medicine Cancer Research medicine.medical_specialty Lung Neoplasms Adolescent endocrine system diseases Population Comorbidity Young Adult Diabetes mellitus Internal medicine medicine Humans Hypoglycemic Agents Lung cancer education Aged education.field_of_study business.industry Cumulative dose Incidence Cancer Middle Aged medicine.disease Polycystic ovary Metformin Surgery Patient Outcome Assessment Diabetes Mellitus Type 2 Oncology Cohort Female business medicine.drug |
| Zdroj: | Lung Cancer. 86:137-143 |
| ISSN: | 0169-5002 |
| DOI: | 10.1016/j.lungcan.2014.09.012 |
| Popis: | Objectives Higher risk of lung cancer has been noted in patients with type 2 diabetes mellitus (DM). Some observational studies have shown a reduced risk of lung cancer in DM patients taking metformin, but a dose–response relationship has never been reported. The aim of this study is to exam the association between the dose of metformin and the incidence of lung cancer in a Chinese population. Materials and methods The dataset used for this nationwide population-based study is a cohort of 1 million subjects randomly sampled from individuals enrolled in the Taiwan National Health Insurance system. We enrolled all subjects with newly diagnosed type 2 DM between 1997 and 2007. Subjects with a diagnosis of neoplasm before DM diagnosis, those using metformin before DM diagnosis, those with polycystic ovary syndrome, and those with a DM diagnosis before their 15 years of age were excluded. The demographic data and duration, cumulative dose and intensity of metformin use were compared between patients developing lung cancer and those without lung cancer. Results Totally, 47,356 subjects were identified. After adjusting for age, gender, and modified Charlson Comorbidity Index score, the utilization of metformin was an independent protecting factor, and the risk of developing lung cancer decreased progressively with either the higher cumulative dose or the higher intensity of metformin use. Conclusions This study revealed that the use of metformin decreased the risk of lung cancer in a dose-dependent manner in patients with type 2 DM. The chemo-preventive effect of metformin deserves further study. |
| Databáze: | OpenAIRE |
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