Evaluation of metallothionein-1, metallothionein-2, lipid peroxidation and trace elements status in the progression of the spontaneous mitral chordae tendineae rupture patients
| Autor: | Nurten Bahtiyar, Mahmut Alp Kılıç, Dursun Çayan Akkoyun, Ali Riza Kiziler, Hakan Cinemre, Fatma Behice Serinkan Cinemre, Birsen Aydemir, Mehmet Bülent Vatan, Ramazan Akdemir |
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| Přispěvatelé: | Aydemir, B, Cinemre, FBS, Cinemre, H, Kiziler, AR, Akdemir, R, Vatan, MB, Kilic, MA, Bahtiyar, N, Akkoyun, DC, Sakarya Üniversitesi/Tıp Fakültesi/Temel Tıp Bilimleri Bölümü, Cinemre, Fatma Behice, Cinemre, Hakan, Akdemir, Ramazan, Vatan, Mehmet Bülent |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Clinical Biochemistry Biochemistry Inorganic Chemistry Lipid peroxidation Trace (semiology) chemistry.chemical_compound Endocrinology & Metabolism medicine.anatomical_structure chemistry Internal medicine Cardiology Medicine Metallothionein Chordae tendineae business |
| Popis: | Objective: The aim of the present study was to investigate whether copper, zinc and iron levels and copper/zinc, iron/zinc, iron/copper ratios in serum and erythrocytes are associated with lipid oxidation levels, metallothionein-1 (MT-1), and metallothionein-2 (MT-2) levels in plasma in the context of pathogenesis of the mitral chordae tendineae rupture (MCTR). Methods: 65 subjects who were identical in demographic characteristics' were selected for the study; 33 with MCTR patients, and 32 healthy control subjects. The levels of MT-1, MT-2, and malondialdehyde as measure of lipid oxidation, and trace elements were determined by enzyme-linked immunosorbent assay, spectrophotometric method, and inductively coupled plasma optical emission spectrometry, respectively. Results: Serum zinc levels were found to be lower in the patients' group when compared to control group. The copper and iron levels in serum, MT-1, MT-2; malondialdehyde levels in plasma, iron and malondialdehyde levels in erythrocytes; serum copper/zinc and iron/zinc ratios were found to be higher in the patients' group when compared to controls. Conclusions: We conclude that the changes of oxidant antioxidant system balance and trace element status may contribute to the etiopathogenesis of MCTR. |
| Databáze: | OpenAIRE |
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