The ureases of Proteus strains in relation to virulence for the urinary tract
| Autor: | N. C. Bradford, B. W. Senior, D. S. Simpson |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Microbiology (medical)
Male Urease Urinary system Virulence Microbiology Isozyme Virulence factor Pathogenesis Species Specificity Humans Proteus vulgaris chemistry.chemical_classification biology General Medicine biology.organism_classification Proteus Isoenzymes Enzyme chemistry Urinary Tract Infections biology.protein Electrophoresis Polyacrylamide Gel Female |
| Zdroj: | Journal of medical microbiology. 13(4) |
| ISSN: | 0022-2615 |
| Popis: | PLATES XXX-XXXII THE ENZYME urease is thought to play a major role as a virulence factor in urinary-tract infections with Proteus (Braude and Siemienski, 1960) although it may not be the only factor (Eudy, Burrous and Sigler, 1971). Urease degrades urea with release of ammonia which may cause damage and death to the renal epithelium, inactivation of complement, and conditions favouring the development of renal stones. Many of these effects can be prevented by the administration of urease inhibitors (Griffith and Musher, 1973; Griffith, Musher and Campbell, 1973; Aronson, Medalia and Griffel, 1974; Musher et al., 1975). Phillips (1955) found wide variation in the pathogenicity of different strains of Proteus for the mouse kidney in vivo, and Senior (1979) has shown that particular proticine-production/sensitivity (P/S) types of P. mirabilis have a special affinity for the urinary tract whereas other P/S types and other Proteus species are seldom incriminated in serious urinary-tract infections. The aim of this study was to determine whether or not these differences in pathogenicity among strains of Proteus were associated with differences in the types of ureases produced by these strains. |
| Databáze: | OpenAIRE |
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