The effect of exercise on anxiety- and depression-like behavior of aged rats
Autor: | O. Gokdemir, C. Cetinkaya, H. Gumus, I. Aksu, M. Kiray, M. Ates, A. Kiray, B. Baykara, A. R. Sisman, N. Uysal |
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Rok vydání: | 2019 |
Předmět: |
0301 basic medicine
Aging Serotonin Elevated plus maze medicine.medical_specialty Histology Prefrontal Cortex Hippocampus Anxiety Amygdala Open field Random Allocation 03 medical and health sciences 0302 clinical medicine Physical Conditioning Animal Internal medicine medicine Animals Rats Wistar Prefrontal cortex 030102 biochemistry & molecular biology Depression business.industry digestive oral and skin physiology General Medicine Rats Medical Laboratory Technology Endocrinology medicine.anatomical_structure 030220 oncology & carcinogenesis Receptor Serotonin 5-HT1A Female medicine.symptom business Selective Serotonin Reuptake Inhibitors Behavioural despair test |
Zdroj: | Biotechnic & Histochemistry. 95:8-17 |
ISSN: | 1473-7760 1052-0295 |
Popis: | We investigated the effects of exercise in multiple sessions on anxiety- and depression-like behavior during aging, and the role of serotonin and serotonin 1A receptors in this process. Both 24-month-old (aged) and 6-month-old (adult) female rats were divided into five groups; aged control, adult control, aged + serotonin re-uptake inhibitors (SSRIs), aged + exercise, and aged + SSRIs + exercise. After exercise, all groups were evaluated using the open field arena, elevated plus maze and forced swim tests. We assessed serum corticosterone levels; number of amygdala, hippocampus and prefrontal cortex cells; tissue serotonin and serotonin 1A (5-HT1A) levels. In the open field test, aged rats exhibited a significant increase in locomotor activity compared to the SSRIs and SSRIs + exercise groups. During the elevated plus maze test, aged rats were observed less frequently in the open arms of assembly compared to adults. The duration increased in the exercise group and remained unchanged in the SSRIs group. In the forced swim test, the aged rats were more immobile compared to adults; no change was observed in the immobility time between these groups. The tissue serotonin levels in amygdala and hippocampus were higher in SSRIs + exercise group compared to the aged, exercised and SSRIs groups. The number of cells in the hippocampus, prefrontal cortex and amygdala decreased in the aged group compared to adult rats; increased numbers of cell were observed in exercise, SSRIs and SSRIs + exercise groups compared to aged rats. Exercise in multiple sessions may increase the number of cells in the hippocampus, prefrontal cortex and amygdala, which may reduce senile anxiety and depression. Also, serotonin and serotonin 1A receptors may play role in depression-like behavior. |
Databáze: | OpenAIRE |
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