Clinicopathologic analysis of uterine sarcomas from a single institution in the Canary Islands
| Autor: | Amina Lubrano, Miguel Andújar, Orlando Falcón, Juan Miguel Falcón, Eva Álvarez, Virginia Benito, Norberto Medina, Octavio Arencibia |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Leiomyosarcoma medicine.medical_specialty Mixed Tumor Mullerian Kaplan-Meier Estimate Disease-Free Survival medicine Humans Stage (cooking) Aged Neoplasm Staging Retrospective Studies Aged 80 and over Gynecology Endometrial stromal sarcoma Uterine sarcoma business.industry Soft tissue sarcoma Obstetrics and Gynecology Cancer Sarcoma Histology Anatomical pathology General Medicine Middle Aged Prognosis medicine.disease Survival Rate Treatment Outcome Spain Multivariate Analysis Uterine Neoplasms Female business Follow-Up Studies |
| Zdroj: | International Journal of Gynecology & Obstetrics. 107:44-49 |
| ISSN: | 0020-7292 |
| Popis: | Objective To evaluate the clinicopathologic data and prognostic factors for patients with uterine sarcomas treated at a single institution, with special emphasis on malignant mixed mullerian tumors (MMMT). Methods Medical and anatomic pathology records were reviewed. Survival rates were analyzed using the Kaplan-Meier method. Results The study included 89 patients: 48.4% with MMMT; 22.4% with leiomyosarcomas; 20.2% with endometrial stromal sarcomas; and 9% with adenosarcomas. FIGO stages I, II, III, and IV were identified in 57.3%, 9.0%, 22.5%, and 7.8% of patients respectively. Event-free survival rates after 2, 5, and 10 years were 70%, 61%, and 55% respectively, with a median time of 90 months (95% CI, 41–140 months). Overall survival rates after 2, 5, and 10 years were 50%, 45%, and 39% respectively, with a median time of 43 months (95% CI, 3–83 months). Multivariate analysis showed that stage, histology, tumor size, and parity had an independent influence on overall survival. Conclusions MMMT are the most aggressive tumors and their behavior strongly resembles that of high-grade endometrial adenocarcinoma. Prognostic factors affecting survival were stage, histology, tumor size, and parity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text