Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo
| Autor: | K. Kirk Shung, Zhongping Chen, Pranav M. Patel, Zhonglie Piao, Qifa Zhou, Youmin He, Jiawen Li, Earl Steward, Dilbahar Mohar, Teng Ma, Mingyue Yu |
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| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Catheters Radiography Coronary Artery Disease Signal-To-Noise Ratio 030204 cardiovascular system & hematology 01 natural sciences Article 010309 optics Coronary artery disease 03 medical and health sciences 0302 clinical medicine Optical coherence tomography In vivo 0103 physical sciences Medicine and Health Sciences Animals Humans Medicine Aorta Abdominal Ultrasonography Interventional Miniaturization Multidisciplinary medicine.diagnostic_test business.industry Ultrasound medicine.disease Coronary Vessels Plaque Atherosclerotic 3. Good health Catheter Ultrasonic sensor Rabbits Tomography business Tomography Optical Coherence Biomedical engineering |
| Zdroj: | Li, Jiawen; Ma, Teng; Mohar, Dilbahar; Steward, Earl; Yu, Mingyue; Piao, Zhonglie; et al.(2015). Ultrafast optical-ultrasonic system and miniaturized catheter for imaging and characterizing atherosclerotic plaques in vivo. Scientific Reports, 5(1). doi: 10.1038/srep18406. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/24x015gf Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | Atherosclerotic coronary artery disease (CAD) is the number one cause of death worldwide. The majority of CAD-induced deaths are due to the rupture of vulnerable plaques. Accurate assessment of plaques is crucial to optimize treatment and prevent death in patients with CAD. Current diagnostic techniques are often limited by either spatial resolution or penetration depth. Several studies have proved that the combined use of optical and ultrasonic imaging techniques increase diagnostic accuracy of vulnerable plaques. Here, we introduce an ultrafast optical-ultrasonic dual-modality imaging system and flexible miniaturized catheter, which enables the translation of this technology into clinical practice. This system can perform simultaneous optical coherence tomography (OCT)-intravascular ultrasound (IVUS) imaging at 72 frames per second safely in vivo, i.e., visualizing a 72 mm-long artery in 4 seconds. Results obtained in atherosclerotic rabbits in vivo and human coronary artery segments show that this ultrafast technique can rapidly provide volumetric mapping of plaques and clearly identify vulnerable plaques. By providing ultrafast imaging of arteries with high resolution and deep penetration depth simultaneously, this hybrid IVUS-OCT technology opens new and safe opportunities to evaluate in real-time the risk posed by plaques, detect vulnerable plaques and optimize treatment decisions. |
| Databáze: | OpenAIRE |
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