Effect of Peritoneal Dialysis Solution on the Antimicrobial Activity of Cephalosporins
| Autor: | Joseph F. John, Daryl H. Appleby |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Cephalosporin Antibiotics Microbial Sensitivity Tests medicine.disease_cause Peritoneal dialysis Microbiology polycyclic compounds Tobramycin Medicine Amikacin business.industry food and beverages Antimicrobial Anti-Bacterial Agents Cephalosporins Solutions Aminoglycosides Staphylococcus aureus Gentamicin Gentamicins business Peritoneal Dialysis medicine.drug |
| Zdroj: | Nephron. 30:341-344 |
| ISSN: | 2235-3186 1660-8151 |
| Popis: | We studied the effect of peritoneal dialysis solution (PDS) on the antibacterial activity of seven cephalosporins, gentamicin, tobramycin and amikacin. The six bacterial species employed in the study survived in a wide range of concentrations of PDS, however, Staphylococcus aureus did not survive beyond 24 h in PDS. There were no physical incompatibilities between any of the antibiotics and PDS. None of the cephalosporins was bactericidal in PDS, whereas, the bactericidal concentrations of the aminoglycosides in PDS approximated those of aminoglycosides in broth. We conclude from these in vitro data that cephalosporins may not be ideal agents for intraperitoneal therapy when they are administered in PDS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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