Systemic allergic reactions induced by labile plant-food allergens: Seeking potential cofactors. A multicenter study
| Autor: | F Murzilli, Alessandro Marra, Giulia Garzi, Ariano R, Danilo Villalta, Valerio Pravettoni, Eleonora Nucera, Elena Pinter, Enrico Scala, Federica Rivolta, Nicoletta Saporiti, Marco De Carli, Mona-Rita Yacoub, Angela Rizzi, Giuliana Zisa, Moira Busa, Massimo Cinquini, Monica Magnani, Camilla Di Paolo, Arianna Aruanno, Riccardo Asero, Stefano Miceli Sopo, G Cortellini, Paolo Borrelli, Fabio Lodi Rizzini, Claudio Barzaghi, Giuseppina Manzotti, Giorgio Celi, Francesca D’Auria |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Alcohol Cross Reactions medicine.disease_cause Immunoglobulin E 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Allergen Oral allergy syndrome Food allergy pollen allergy anaphylaxis Immunology and Allergy Medicine Ingestion Humans Sensitization food allergy Plant Proteins Retrospective Studies biology business.industry digestive oral and skin physiology Allergens Antigens Plant medicine.disease 030104 developmental biology medicine.anatomical_structure 030228 respiratory system chemistry Settore MED/38 - PEDIATRIA GENERALE E SPECIALISTICA biology.protein business Anaphylaxis Food Hypersensitivity |
| Zdroj: | AllergyREFERENCES. 76(5) |
| ISSN: | 1398-9995 |
| Popis: | BACKGROUND Heat-and-pepsin-sensitive plant food allergens (PR-10 and profilin) sometimes cause systemic reaction. OBJECTIVE To detect the risk factors for systemic reactions induced by labile food allergens. METHODS A retrospective multicenter study was performed on patients with a documented history of systemic allergic reaction to labile plant food allergens and on age-matched controls with a history of oral allergy syndrome (OAS) induced by the same foods. Offending foods, their amount, and state (solid or liquid), and potential cofactors (nonsteroidal anti-inflammatory drugs, protonic pump inhibitors, exercise, alcohol, and fasting) were considered. RESULTS We studied 89 patients and 81 controls. Sensitization to PR-10 or profilin, IgE to Bet v 1 and/or Bet v 2, and foods causing OAS were similar in the two groups. Twenty patients experienced >1 systemic allergic reaction. Tree nuts, Rosaceae, Apiaceae, and soymilk were the main offending foods. Seventeen (19%) patients were taking a PPI when the systemic reaction occurred (vs 5% in controls; P |
| Databáze: | OpenAIRE |
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