Cardiac magnetic resonance imaging in dilated cardiomyopathy in adults--towards identification of myocardial inflammation
| Autor: | Moritz Wagner, Matthias Taupitz, Craig Butler, Mark Beling, Merve Ece Idiz, Karin Klingel, Antje Voigt, Dietmar Kivelitz, Rene Schilling, Reinhard Kandolf, Karl Stangl, Thomas Elgeti, Tahir Durmus |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Cardiomyopathy Dilated Male medicine.medical_specialty Myocarditis Biopsy Cardiomyopathy Inflammation Gadolinium Sensitivity and Specificity Cardiac magnetic resonance imaging Internal medicine medicine Edema Humans Radiology Nuclear Medicine and imaging cardiovascular diseases Neuroradiology Retrospective Studies medicine.diagnostic_test business.industry Myocardium Magnetic resonance imaging Dilated cardiomyopathy General Medicine Middle Aged equipment and supplies musculoskeletal system medicine.disease Magnetic Resonance Imaging Echocardiography cardiovascular system Cardiology Female Radiology medicine.symptom business human activities |
| Zdroj: | European radiology. 21(5) |
| ISSN: | 1432-1084 |
| Popis: | To assess active myocardial inflammation by cardiovascular magnetic resonance (CMR) and endomyocardial biopsy (EMB) amongst adult patients with dilated cardiomyopathy (DCM).We evaluated 23 adults with chronic DCM, who had successfully undergone both CMR and EMB within 3.5 ± 2.6 days. EMB was considered the gold standard. CMR assessment of myocardial inflammation used the following parameters as recommended by the recently published "Lake Louise Criteria": global myocardial oedema, global relative enhancement (RE), and late gadolinium enhancement (LGE). According to "Lake Louise Criteria", myocardial inflammation was diagnosed if two or more of the three above-mentioned parameters were positive.Myocardial inflammation was confirmed by immunohistology in 12 patients (52.2%). Sensitivity, specificity, and diagnostic accuracy of CMR to detect immunohistologically confirmed myocardial inflammation were 75.0%, 72.7%, and 73.9%, respectively. Sensitivity, specificity, and diagnostic accuracy of the individual CMR parameters to detect myocardial inflammation were as follows: global myocardial oedema, 91.7%, 81.8%, and 87.0%, respectively; global RE, 58.3%, 63.6%, and 60.9%, respectively; LGE, 58.3%, 45.4%, and 52.2%, respectively.Global myocardial oedema was identified as a promising CMR parameter for assessment of myocardial inflammation in patients with DCM. In these patients, global myocardial oedema yielded superior diagnostic performance compared to "Lake Louise Criteria". |
| Databáze: | OpenAIRE |
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