Frequencies of PD-1- positive T CD3+CD4+, T CD3+CD8+ and B CD19+ lymphocytes in female patients with Graves' disease and healthy controls– preliminary study
| Autor: | Jacek Roliński, Dawid Pyzik, Agata Smoleń, Ewelina Grywalska, Beata Matyjaszek-Matuszek, Aleksandra Pyzik |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Graves' disease CD3 Programmed Cell Death 1 Receptor Biochemistry CD19 Pathogenesis 03 medical and health sciences 0302 clinical medicine Endocrinology Antigens CD Internal medicine Female patient medicine Humans Lymphocyte Count Molecular Biology B-Lymphocytes biology business.industry Mean fluorescence intensity Middle Aged Flow Cytometry medicine.disease Graves Disease 030104 developmental biology Case-Control Studies Immunology Etiology biology.protein Female business CD8 030215 immunology |
| Zdroj: | Molecular and Cellular Endocrinology. |
| ISSN: | 0303-7207 |
| DOI: | 10.1016/j.mce.2017.03.006 |
| Popis: | PD-1 maintains tolerance and inhibits autoimmune responses. Graves' disease (GD) is one of the most frequent autoimmune diseases of unclear etiology. The aim of this study was to evaluate the percentage and absolute counts of PD-1 positive T and B cells in newly diagnosed, untreated patients with hyperthyroidism due to GD. The study group included 30 patients and the control group comprised of 20 age- and sex-matched healthy individuals. Results showed significantly higher frequencies and absolute counts of PD-1 positive CD3+CD4+ T cells, CD3+CD8+ T cells and CD19+B cells in patients with GD in comparison to the healthy volunteers. Moreover, higher mean fluorescence intensity of PD-1 was found on CD3+CD4+ T cells, CD3+CD8+ T cells and CD19+B cells in the study group than in the control group. These results suggest that PD-1 protein might involved in the pathogenesis of GD. |
| Databáze: | OpenAIRE |
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