Growth Hormone Treatment in Noonan Syndrome: Report of Four Cases Who Reached Final Height
| Autor: | F. Passeri, G. Municchi, Stefano Cianfarani, A. M. Pasquino, Ida Pucarelli |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
Adolescent Endocrinology Diabetes and Metabolism Growth hormone Short stature Endocrinology Age Determination by Skeleton Internal medicine Humans Medicine Child business.industry Human growth hormone Noonan Syndrome Final height Bone age Chronological age medicine.disease Body Height Recombinant Proteins Growth hormone treatment Growth Hormone Noonan syndrome Female medicine.symptom business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1423-0046 0301-0163 |
| Popis: | Final height of 4 patients with Noonan syndrome and short stature treated with growth hormone (GH) is reported. Four prepubertal girls (chronological age 12.3-15.1 years, bone age 11.0-11.5 years) were treated with recombinant human growth hormone (0.5 IU/kg/week s.c.) for at least 3 years. Stimulated GH secretion was normal, spontaneous nocturnal GH secretion was low in 1 patient. Final height, as standard deviation score according to Ranke-specific standards for Noonan syndrome, improved in 3 patients and 2 of the exceeded their corrected midparental height. |
| Databáze: | OpenAIRE |
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