Gender difference in relationship between serum ferritin and 25-hydroxyvitamin D in Korean adults

Autor: Kyu Su Lee, Mi Young Gi, Hyun Yoon, Jeong Min Seong, Yo Sang Yoon, Nan Young Bae
Rok vydání: 2017
Předmět:
Male
0301 basic medicine
Physiology
lcsh:Medicine
Organic chemistry
Biochemistry
Endocrinology
0302 clinical medicine
Sex factors
Regular exercise
Vitamin D
lcsh:Science
Serum ferritin
Alcohol Consumption
Multidisciplinary
Anemia
Vitamins
Hematology
Middle Aged
Physical sciences
Postmenopause
Chemistry
Nutritional deficiencies
Female
Research Article
Adult
medicine.medical_specialty
National Health and Nutrition Examination Survey
030209 endocrinology & metabolism
vitamin D deficiency
Chemical compounds
03 medical and health sciences
Sex Factors
Internal medicine
Organic compounds
Republic of Korea
medicine
Vitamin D and neurology
Humans
Iron Deficiency Anemia
Nutrition
Aged
Medicine and health sciences
Ferritin
Vitamin D deficiency
Postmenopausal women
Endocrine Physiology
Serum Ferritin Levels
business.industry
lcsh:R
Biology and Life Sciences
Proteins
Protein Complexes
Estrogens
medicine.disease
Hormones
Diet
030104 developmental biology
Premenopause
Ferritins
lcsh:Q
Insulin Resistance
business
Zdroj: PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0177722 (2017)
ISSN: 1932-6203
Popis: Background The present study was conducted to assess the gender difference in the relationship between serum ferritin and 25-hydroxyvitamin D [25(OH)D] in Korean adults. Methods A total of 5,147 adults (2,162 men, 1,563 premenopausal women, and 1,422 postmenopausal women) aged ≥ 20 years from the Korean National Health and Nutrition Examination Survey (KNHANES) data (2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D status (vitamin D deficiency, 25(OH)D < 10.0 ng/mL; vitamin D insufficiency, 25(OH)D ≥ 10.0, < 20.0 ng/mL; vitamin D sufficiency, 25(OH)D ≥ 20.0 ng/mL). Results The key study results were as follows: First, in men, in terms of serum ferritin levels by serum 25(OH)D level after adjusting for age, smoking, alcohol drinking, regular exercise, SBP, DBP, WM. TC, TGs, HDL-C, FPG, Hb, Hct, MCV, and Fe, serum ferritin levels were inversely increased with the increasing of serum 25(OH)D level (P = 0.012). Second, in premenopausal women, after adjusting for related variables, serum ferritin levels were increased with the increasing of serum 25(OH)D level (P = 0.003). Third, in postmenopausal women, after adjusting for related variables, serum ferritin levels were not significantly increased with the increasing of serum 25(OH)D level (P = 0.456). Conclusion Serum 25(OH)D level was inversely associated with the serum ferritin levels in men, but was positively associated with the serum ferritin levels in premenopausal women, and was not associated with the serum ferritin levels in postmenopausal women.
Databáze: OpenAIRE
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