| Autor: |
Suteeraporn Chaowattanapanit, Rachot Wongjirattikarn, Nipon Chaisuriya, Piti Ungarreevittaya, Pirawan Poosekeaw, Kengkart Winaikosol, Charoen Choonhakarn, Narachai Julanon, Kanin Salao |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Therapeutic advances in chronic disease. 13 |
| ISSN: |
2040-6223 |
| Popis: |
Background: Prurigo nodularis (PN) is a chronic pruritic skin disease which can greatly impact patients’ quality of life. Moreover, the pathogenesis remains unclear, making it a difficult-to-treat condition. Aims: To investigate the expression of interleukin-31 (IL-31) in serum and skin biopsy specimens of PN patients and healthy subjects and identify its possible correlation to disease severity and itch intensity. Methods: Patients with PN and healthy volunteers were recruited for the study. Expression levels of IL-31 were measured by enzyme-linked immunosorbent assay and immunohistochemistry. Baseline characteristics, disease activity, itch intensity, and related laboratory results were collected. Results: Forty-three PN patients and 31 healthy subjects participated in our study. The PN patients had significantly higher mean serum IL-31 levels than the healthy subjects (52.9 ± 18.2 versus 36.3 ± 10.7 pg/ml, p Conclusion: Increased IL-31 expression in serum and PN lesions suggests that IL-31 has a potential role in the pathogenesis of PN. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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