Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats
| Autor: | Müjdat Uysal, Güldal Mehmetçik, Gül Özdemirler, Gülçin Toker, Öznur Kanbagli |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
chemistry.chemical_classification
Aging medicine.medical_specialty Very low-density lipoprotein Health (social science) Antioxidant Apolipoprotein B biology Vitamin E medicine.medical_treatment Fatty acid Malondialdehyde Lipid peroxidation chemistry.chemical_compound Endocrinology chemistry Biochemistry Internal medicine medicine biology.protein lipids (amino acids peptides and proteins) Geriatrics and Gerontology Gerontology Polyunsaturated fatty acid |
| Zdroj: | Archives of Gerontology and Geriatrics. 25:305-310 |
| ISSN: | 0167-4943 |
| DOI: | 10.1016/s0167-4943(97)00023-x |
| Popis: | This study was carried out on young (20–35 years) and old (60–85 years) men and rats (6 vs 22 months) to investigate the effect of aging on plasma lipid peroxidation and the antioxidant system. Plasma polyunsaturated fatty acid (PUFA), total fatty acid (TFA) and malondialdehyde (MDA) levels increased in aged humans and rats compared with young groups. However, plasma MDA/TFA ratios did not increase in aged humans and rats. Plasma vitamin E/TFA, and total thiol content were found to decrease both in aged humans and rats. Plasma antioxidant activity (AOA) decreased only in aged rats. In addition, the susceptibility of VLDL+LDL, apolipoprotein B containing lipoproteins to copper-induced peroxidation increased with aging. It is concluded that aging is associated with some variations in plasma oxidant–antioxidant balance. |
| Databáze: | OpenAIRE |
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