Masked crystalline light chain tubulopathy and podocytopathy with focal segmental glomerulosclerosis: a rare MGRS-associated renal lesion
| Autor: | Linda B. Moran, Maria Atta, H. Terence Cook, Frederick W.K. Tam, Stephen P. McAdoo, Sarah Blakey, Candice Roufosse, Aristeidis Chaidos, Andreas Kousios |
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| Přispěvatelé: | Imperial College Healthcare NHS Trust- BRC Funding, Imperial College Healthcare NHS Trust |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Renal lesion
Pathology medicine.medical_specialty Histology Paraproteinemias Immunoglobulin light chain Kidney light chain tubulopathy Pathology and Forensic Medicine podocytopathy Focal segmental glomerulosclerosis Tubulopathy Medicine Humans focal segmental glomerulosclerosis Science & Technology business.industry Glomerulosclerosis Focal Segmental Podocytes 1103 Clinical Sciences General Medicine Cell Biology Middle Aged medicine.disease Monoclonal gammopathy of renal significance business Life Sciences & Biomedicine |
| Popis: | Monoclonal Gammopathy of Renal Significance (MGRS) encompasses a wide spectrum of histopathology. Characterizing rare forms of MGRS-related renal pathology remains work in progress. Light chain crystalline podocytopathy in the context of MGRS, either in isolation or combined with proximal tubulopathy (LCPT) has rarely been described. Unravelling MGRS pathologies is critical for patient management and often requires ancillary techniques for antigen retrieval to demonstrate light chain (LC) restriction on immunofluorescence (IF). |
| Databáze: | OpenAIRE |
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