Rules for Peptide Presentation by MHC Class II Molecules
| Autor: | Janeway Ca, Rudensky AYu, Mamula Mj |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Antigen Presentation
MHC class II biology CD74 Antigen processing Histocompatibility Antigens Class I Molecular Sequence Data Immunology Histocompatibility Antigens Class II CD1 Human leukocyte antigen MHC restriction Major histocompatibility complex surgical procedures operative MHC class I biology.protein Animals Immunology and Allergy Amino Acid Sequence Peptides |
| Zdroj: | International Reviews of Immunology. 10:301-311 |
| ISSN: | 1563-5244 0883-0185 |
| DOI: | 10.3109/08830189309061705 |
| Popis: | Molecules of the major histocompatibility complex (MHC) were first discovered for their importance in the Rejection of tissue grafts between unrelated individuals. If these individuals differ at one or more loci within the MHC, the grafts are Rapidly Rejected. The Rejection process involves Recognition of foreign MHC molecules by T lymphocytes and the Rapid destruction by these cells of the grafted tissue cells. The MHC is a highly polymorphic complex of genes, making tissue grafting between unrelated individuals virtually impossible. Thus, it stimulated a great deal of work when organ transplantation became technically feasible. |
| Databáze: | OpenAIRE |
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