Age-induced and photoinduced changes in gene expression profiles in facial skin of Caucasian females across 6 decades of age
| Autor: | Joyce Y. Tung, Alexa B. Kimball, Nikki E. Annunziata, Raghu Kainkaryam, Dionne D. Swift, Heather L. Rocchetta, Xianghong Yan, Robert J. Isfort, Makio Tamura, Jun Xu, Emily D. Conley, Robert Lloyd Binder, Bradley B. Jarrold, Lisa Ann Mullins, Chieko Soh, Charles C. Bascom, Neil Houston, Rosemarie Osborne, Kazumi Toyama, Jay P. Tiesman, Maria B. Alora-Palli |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Senescence Adult Pathology medicine.medical_specialty Ultraviolet Rays Dermatology White People Skin Aging Transcriptome 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Forearm Risk Factors Gene expression medicine Humans Genetic Predisposition to Disease Buttocks Genotyping Aged Aged 80 and over integumentary system medicine.diagnostic_test business.industry Biopsy Needle Middle Aged Prognosis Immunohistochemistry 030104 developmental biology medicine.anatomical_structure Skin biopsy Female business Facial Dermatoses |
| Zdroj: | Journal of the American Academy of Dermatology. 78(1) |
| ISSN: | 1097-6787 |
| Popis: | Background Intrinsic and extrinsic factors, including ultraviolet irradiation, lead to visible signs of skin aging. Objective We evaluated molecular changes occurring in photoexposed and photoprotected skin of white women 20 to 74 years of age, some of whom appeared substantially younger than their chronologic age. Methods Histologic and transcriptomics profiling were conducted on skin biopsy samples of photoexposed (face and dorsal forearm) or photoprotected (buttocks) body sites from 158 women. 23andMe genotyping determined genetic ancestry. Results Gene expression and ontologic analysis revealed progressive changes from the 20s to the 70s in pathways related to oxidative stress, energy metabolism, senescence, and epidermal barrier; these changes were accelerated in the 60s and 70s. The gene expression patterns from the subset of women who were younger-appearing were similar to those in women who were actually younger. Limitations Broader application of these findings (eg, across races and Fitzpatrick skin types) will require further studies. Conclusions This study demonstrates a wide range of molecular processes in skin affected by aging, providing relevant targets for improving the condition of aging skin at different life stages and defining a molecular pattern of epidermal gene expression in women who appear younger than their chronologic age. |
| Databáze: | OpenAIRE |
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