Chelates of dicumarol I: Preparation and structure identification of magnesium chelate
| Autor: | R.J. Spivey, Lyle D. Bighley |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Thermogravimetric analysis
Dicumarol Chromatography Gas Differential Thermal Analysis Magnetic Resonance Spectroscopy Chemical Phenomena Spectrophotometry Infrared Magnesium Spectrophotometry Atomic Inorganic chemistry Pharmaceutical Science Infrared spectroscopy chemistry.chemical_element Endothermic process Oxygen Carbon Chemistry chemistry Melting point Chelation Stoichiometry Densitometry Hydrogen |
| Zdroj: | Journal of pharmaceutical sciences. 66(8) |
| ISSN: | 0022-3549 |
| Popis: | A magnesium chelate of dicumarol was prepared by reacting a suspension of dicumarol and magnesium oxide in 50% water-methanol. GLC, thermogravimetric, and elemental analyses showed that this compound has a 2:1 ligand-metal stoichiometry with 2 moles of water associated with the complex. Although the chelate does not melt, two endothermic peaks at 205 and 274 degrees were observed in the thermogram, in contrast to a single endothermic peak corresponding to a melting point of 288 degrees for dicumarol. IR spectroscopy indicated that the magnesium is bonded between the carbonyl at C-2 and the oxygen at C-4' (or vice versa). |
| Databáze: | OpenAIRE |
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