Melatonin: An atypical hormone with major functions in the regulation of angiogenesis
| Autor: | Javad Jalili, Ainaz Mihanfar, Mohammad Mirza-Aghazadeh-Attari, Parisa Hajalioghli, Russel J. Reiter, Reza Rikhtegar, Maryam Majidinia, Bahman Yousefi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Angiogenesis Clinical Biochemistry Neovascularization Physiologic Apoptosis Pharmacology Biology Biochemistry Antioxidants Melatonin 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Genetics medicine Humans Receptor Molecular Biology Reactive nitrogen species chemistry.chemical_classification Reactive oxygen species Gene Expression Regulation Developmental Cell Biology Reactive Nitrogen Species Circadian Rhythm Vascular endothelial growth factor 030104 developmental biology chemistry 030220 oncology & carcinogenesis Reactive Oxygen Species Hormone medicine.drug |
| Zdroj: | IUBMB Life. 72:1560-1584 |
| ISSN: | 1521-6551 1521-6543 |
| DOI: | 10.1002/iub.2287 |
| Popis: | Melatonin (N-acetyl-5-methoxytryptamine), a pleotropic molecule with a wide distribution, has received considerable attention in recent years, mostly because of its various major effects on tissues or cells since it has both receptor-dependent and receptor-independent actions over a wide range of concentrations. These biological and physiological functions of melatonin include regulation of circadian rhythms by modulating the expression of core oscillator genes, scavenging the reactive oxygen species and reactive nitrogen species, modulating the immune system and inflammatory response, and exerting cytoprotective and antiapoptotic effects. Given the multiple critical roles of melatonin, dysregulation of its production or any disruption in signaling through its receptors may have contributed in the development of a wide range of disorders including type 2 diabetes, aging, immune-mediated diseases, hypertension, and cancer. Herein, we focus on the modulatory effects of melatonin on angiogenesis and its implications as a therapeutic strategy in cancer and related diseases. |
| Databáze: | OpenAIRE |
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