Estradiol and Chlordecone (Kepone) Decrease Adenosine 3'5'-Cyclic Monophosphate Concentrations in the Ovariectomized Immature Rat Uterus
| Autor: | S. Chatterjee, S. Banerjee, Donald C. Johnson |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
medicine.medical_specialty
medicine.drug_class Ovariectomy Estrogen receptor General Biochemistry Genetics and Molecular Biology Adenylyl cyclase chemistry.chemical_compound Internal medicine Cyclic AMP medicine Animals Fulvestrant Forskolin Estradiol Colforsin Uterus Estrogen Antagonists Organ Size Adenosine Rats Kinetics Endocrinology chemistry Chlordecone Estrogen Estradiol benzoate Ovariectomized rat Kepone Female hormones hormone substitutes and hormone antagonists Adenylyl Cyclases medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 210:33-38 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | Adenosine 3'5'-cyclic monophosphate (cAMP) has been repeatedly shown to mimic some actions of estrogen in the rat uterus. However, the relationship between estrogens and uterine cAMP remains controversial. The effect of chronic exposure (3 days) to a biologically potent, long-acting estrogen, estradiol benzoate (EB), or the xenoestrogen chlordecone (Kepone), which has a long half-life in the circulation, was examined in ovariectomized immature rats. Both compounds, when administered in doses that provided equal increases in uterine weight, produced equivalent decreases in uterine cAMP content. Although the decrease in cAMP was apparent within 48 hr, it was more pronounced at 72 hr. There was no reduction in cAMP produced in response to direct stimulation of uterine adenylyl cyclase by forskolin, indicating that loss of the enzyme was not a factor in the lowering of cAMP content. The pure anti-estrogen ICI-182,780, in a dose-dependent fashion, prevented the action the estradiol benzoate and chlordecone, suggesting that the lowering of cAMP was dependent on an estrogen receptor. The physiological significance of reduced uterine cAMP with chronic estrogen treatment remains to be determined. |
| Databáze: | OpenAIRE |
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