Novel antibacterial calcium phosphate nanocomposite with long-term ion recharge and re-release to inhibit caries
| Autor: | Haohao Wang, Michael D. Weir, Yuxing Bai, Bashayer H. Baras, Ghalia Bhadila, Gary D. Hack, Mary Ann S. Melo, Hockin H.K. Xu |
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| Rok vydání: | 2020 |
| Předmět: |
Calcium Phosphates
Dental composite Materials science 0206 medical engineering chemistry.chemical_element 02 engineering and technology Dental Caries Calcium Nanocomposites Ion 03 medical and health sciences 0302 clinical medicine Humans Amorphous calcium phosphate General Dentistry Remineralisation Nanocomposite Biofilm 030206 dentistry 020601 biomedical engineering Anti-Bacterial Agents chemistry Biofilms Ceramics and Composites Methacrylates Dimethylaminododecyl methacrylate Nuclear chemistry |
| Zdroj: | Dental Materials Journal. 39:678-689 |
| ISSN: | 1881-1361 0287-4547 |
| Popis: | Short-term studies on calcium-phosphate (CaP) ion-rechargeable composites were reported. The long-term rechargeability is important but unknown. The objectives of this study were to investigate nanocomposite with strong antibacterial and ion-recharge capabilities containing dimethylaminododecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP), and evaluate long-term ion-recharge by testing for 12 cycles (taking 6 months to complete) for the first time. Three groups were tested: (1) Heliomolar control; (2) Resin+20%NACP+50%glass; (3) Resin+3%DMAHDM+20%NACP+50%glass. Biofilm acid and colony-forming units (CFU) were measured. Ion-recharge was tested for 12 cycles. NACP-DMAHDM composite reduced biofilm acid, and reduced CFU by 4 logs. High levels of ion releases were maintained throughout 12 cycles of recharge, maintaining steady-state releases without reduction in 6 months (p>0.1), representing long-term remineralization potential. Bioactive nanocomposite demonstrated long-term ion-rechargeability for the first time, showed remineralization and potent anti-biofilm functions, with promise for tooth restorations to combat caries. |
| Databáze: | OpenAIRE |
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