D-fenfluramine challenge in posttraumatic stress disorder
| Autor: | F G Moeller, Lori L. Davis, Frederick Petty, Gerald L. Kramer, David M. Clark |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Time Factors Fenfluramine Neuroregulation Behavioral Symptoms behavioral disciplines and activities Serotonin Agents mental disorders medicine Humans Single-Blind Method Longitudinal Studies Survivors Psychiatry Biological Psychiatry Veterans Analysis of Variance Combat Disorders Aggression Middle Aged medicine.disease United States Prolactin Vietnam Area Under Curve Case-Control Studies Anxiety medicine.symptom Psychology Reuptake inhibitor Anxiety disorder medicine.drug |
| Zdroj: | Biological Psychiatry. 45:928-930 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/s0006-3223(98)00215-7 |
| Popis: | Background: Much progress has been made in understanding the role of catecholamines in the pathophysiology of posttraumatic stress disorder (PTSD). Recent research has broadened the scope of neuroregulation of PTSD to include serotonin. Methods: We used the serotonin-releasing agent and reuptake inhibitor, d-fenfluramine, to assess the integrity of the serotonin-mediated prolactin release in 8 men with combat-induced PTSD and 8 healthy men. Results: The veterans with PTSD had a significantly lower prolactin response to d-fenfluramine as compared to healthy control subjects. The prolactin response to d-fenfluramine was inversely correlated with the patient’s level of PTSD symptomatology and measures of aggression. Conclusions: This study demonstrates a central serotonin dysfunction, as reflected in a lower prolactin response to d-fenfluramine, in patients with PTSD. |
| Databáze: | OpenAIRE |
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