Corrigendum to 'Oxidative Stress-Related Parthanatos of Circulating Mononuclear Leukocytes in Heart Failure'
| Autor: | Zsuzsanna Mezei, Rita Benkő, Endre Zima, Tamás Bárány, Levente Molnár, Dávid Becker, Andrea Simon, Eszter M. Horváth, Béla Merkely, G Szabo |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Heart Failure
Male Aging business.industry lcsh:Cytology Cell Biology General Medicine Middle Aged medicine.disease_cause medicine.disease Biochemistry Parthanatos Oxidative Stress Heart failure Immunology medicine Leukocytes Mononuclear Humans Female lcsh:QH573-671 business Corrigendum Oxidative stress Aged |
| Zdroj: | Oxidative Medicine and Cellular Longevity Oxidative Medicine and Cellular Longevity, Vol 2019 (2019) |
| ISSN: | 1942-0994 1942-0900 |
| Popis: | The present study aims to examine the oxidative stress-related activation of poly(ADP-ribose) polymerase (PARP), a cause of parthanatos in circulating mononuclear leukocytes of patients with chronic heart failure (CHF), that was rarely investigated in the human setting yet.Patients with CHF (Plasma PRX, leukocyte HNE, NT, PARylation, and AIF translocation were significantly higher in the heart failure group. Pro-BNP levels in all study subjects showed a significant positive correlation to PRX, OSI, leukocyte HNE, NT, PARylation, and AIF translocation. Ejection fraction negatively correlated with the same parameters. Among HF patients, a positive correlation of pro-BNP with PRX, OSI, and PARylation was still present.Markers of oxidative-nitrative stress, PARP activation, and AIF translocation in blood components showed correlation to reduced cardiac function and the clinical appearance of CHF. These results may reinforce the consideration of PARP inhibition as a potential therapeutic target in CHF. |
| Databáze: | OpenAIRE |
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