MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review
| Autor: | Sven Niklander, C. Marín, F. Contreras, D. Guerra, Wilfredo Alejandro González-Arriagada |
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| Rok vydání: | 2022 |
| Předmět: |
Oncology
medicine.medical_specialty cone-beam computed tomography MEDLINE Review Malignant transformation stomatognathic system Oral Cancer and Potentially malignant disorders Internal medicine microRNA medicine Humans Prospective Studies Prospective cohort study General Dentistry UNESCO:CIENCIAS MÉDICAS salivary gland calculi Mouth neoplasm Mesh term business.industry Carcinoma in situ medicine.disease observer variation Oral leukoplakia MicroRNAs stomatognathic diseases Cell Transformation Neoplastic Otorhinolaryngology Mouth Neoplasms Surgery Leukoplakia Oral business |
| Zdroj: | Niklander, S., Guerra, D., Contreras, F., González-Arriagada, W., & Marín, C. (2022). MicroRNAs and their role in the malignant transformation of oral leukoplakia: a scoping review. En Medicina Oral Patología Oral y Cirugia Bucal (pp. e77-e84). Medicina Oral, S.L. https://doi.org/10.4317/medoral.24975 Medicina Oral, Patología Oral y Cirugía Bucal |
| ISSN: | 1698-6946 |
| DOI: | 10.4317/medoral.24975 |
| Popis: | Background MiRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level and have been associated with malignant transformation of oral epithelial precursor lesions such as oral leukoplakia. The aim was to perform a scoping review of the contemporary literature about the different roles of miRNAs during the malignant transformation of oral leukoplakia. Material and Methods We conducted a systematic search with the following MeSH terms: ‘oral leukoplakia’, ‘carcinoma in situ’, ‘microRNAs’, ‘mouth neoplasms’ and ‘epithelial–mesenchymal transition’ in PubMed/MEDLINE, EMBASE and SpringerLink. Results Fifteen articles were included for analysis, among which in vivo and in vitro articles were included. A total of 21 different miRNAs were found to be involved in the malignant transformation process of oral leukoplakia. Regarding their possible effects, 6 miRNAs were classified as oncogenic, 5 as tumour suppressors and 10 were related to epithelial–mesenchymal transition, invasion and migration. Conclusions Based on the current review, we concluded that miRNAs-21, 345, 181-b and 31* seem to be potential markers of malignant transformation of oral leukoplakia. However, further clinical prospective studies are needed in order to validate their utility as prognostic biomarkers. Key words:miRNAs, oral leukoplakia, oral squamous cell carcinoma, biomarkers, malignant transformation. |
| Databáze: | OpenAIRE |
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