Physical training improves non-spatial memory, locomotor skills and the blood brain barrier in diabetic rats
| Autor: | Caren Bernardi, Priscylla Nunes de Senna, Carlos Alberto Gonçalves, Pamela Brambilla Bagatini, Matilde Achaval, Fabiana Galland, Patrícia Nardin, Caroline Zanotto, Lisiani Saur, Léder Leal Xavier |
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| Rok vydání: | 2015 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Hippocampus Physical exercise Striatum Blood–brain barrier Streptozocin Diabetes Mellitus Experimental Neurochemical Internal medicine Diabetes mellitus Physical Conditioning Animal medicine Reaction Time Animals Claudin-5 Rats Wistar Molecular Biology Aquaporin 4 Type 1 diabetes Analysis of Variance Memory Disorders General Neuroscience Body Weight Recognition Psychology medicine.disease Streptozotocin Rats Endocrinology medicine.anatomical_structure nervous system Blood-Brain Barrier Motor Skills Exercise Test Exploratory Behavior Neurology (clinical) Psychology Neuroscience Developmental Biology medicine.drug |
| Zdroj: | Brain research. 1618 |
| ISSN: | 1872-6240 |
| Popis: | Type 1 diabetes mellitus (T1DM) progressively affects cognitive domains, increases blood-brain barrier (BBB) permeability and promotes neurovascular impairment in specific brain areas. Physical exercise, on the other hand, has beneficial effects on brain functions, improving learning and memory. This study investigated the effects of treadmill training on cognitive and motor behavior, and on the expression of proteins related to BBB integrity, such as claudin-5 and aquaporin-4 (AQP4) in the hippocampus and striatum in diabetic rats. For this study, 60 Wistar rats were divided into four groups (n=15 per group): non-trained control (NTC), trained control (TC), non-trained diabetic (NTD), trained diabetic (TD). After diabetic induction of 30 days by streptozotocin injection, the exercise groups were submitted to 5 weeks of running training. After that, all groups were assessed in a novel object-recognition task (NOR) and the rotarod test. Additionally, claudin-5 and AQP4 levels were measured using biochemical assays. The results showed that exercise enhanced NOR task performance and rotarod ability in the TC and TD animals. Diabetes produced a decrease in claudin-5 expression in the hippocampus and striatum and reduced AQP4 in the hippocampus. Exercise preserved the claudin-5 content in the striatum of TD rats, but not in the hippocampus. The reduction of AQP4 levels produced by diabetes was not reversed by exercise. We conclude that exercise improves short-term memory retention, enhances motor performance in diabetic rats and affects important structural components of the striatal BBB. The results obtained could enhance the knowledge regarding the neurochemical benefits of exercise in diabetes. |
| Databáze: | OpenAIRE |
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