Short and long-term effects of growth hormone treatment on bone turnover and bone mineral content in adult growth hormone-deficient males
| Autor: | Paul Taelman, Jean-Marc Kaufman, Mark Vandeweghe |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism Urinary system Bone remodeling chemistry.chemical_compound Hydroxyproline Endocrinology Double-Blind Method Bone Density Internal medicine medicine Humans Creatinine biology business.industry Growth hormone treatment Procollagen peptidase chemistry Growth Hormone Osteocalcin biology.protein Alkaline phosphatase Bone Remodeling business Follow-Up Studies |
| Zdroj: | Clinical endocrinology. 39(4) |
| ISSN: | 0300-0664 |
| Popis: | Summary OBJECTIVE In view of the fact that GH-deficient adults present with pronounced osteopaenia and can be considered at risk for osteoporotic fractures, we wanted to investigate the effects of biosynthetic GH replacement therapy (0.25 IU/kg/week) on biochemical indices of bone turnover and on bone mineral content (BMC) in a group of GH-deficient adult males. DESIGN We performed a 6-month randomized, double-blind, placebo-controlled study, followed by 12–24 months of GH treatment in all patients. PATIENTS Twenty adult males with GH deficiency of childhood onset were studied. MEASUREMENTS We measured serum IGF-I, serum phosphate, biochemical indices of bone turnover (serum alkaline phosphatase activity, serum osteocalcin, serum carboxyterminal propeptide of type-I procollagen, fasting urinary hydroxyproline/creatinine and calcium/creatinine ratios) and bone mineral content, measured at the forearm and the lumbar spine by single and dual-photon absorptiometry respectively. RESULTS After 3 and 6 months of GH administration, the serum levels of alkaline phosphatase, osteocalcin and carboxyterminal propeptide of type-I procollagen, and the fasting urinary hydroxyproline/creatinine ratio were significantly increased compared to placebo-treated patients (P |
| Databáze: | OpenAIRE |
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