Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes
| Autor: | Mireia Jové, Ricardo Rodríguez-Calvo, Anna Planavila, Manuel Vázquez-Carrera, Walter Wahli, Liliane Michalik, Juan C. Laguna |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Physiology Peroxisome proliferator-activated receptor Cardiomegaly Acetates Biology Ligands GW0742 Phenoxyacetates Muscle hypertrophy Rats Sprague-Dawley Phenylephrine Phenols Physiology (medical) Internal medicine medicine Animals Myocyte Myocytes Cardiac Electrophoretic mobility shift assay PPAR delta Receptor PPAR-beta Cells Cultured Chemokine CCL2 chemistry.chemical_classification Kinase Activator (genetics) NF-kappa B Lipid Metabolism Rats Endocrinology Acetic Acids/pharmacology Animals Newborn Cardiomegaly/metabolism Cardiomegaly/pathology Chemokine CCL2/metabolism Gene Expression Regulation/drug effects Lipopolysaccharides/pharmacology Myocytes Cardiac/drug effects Myocytes Cardiac/pathology NF-kappa B/metabolism PPAR delta/agonists PPAR delta/physiology PPAR-beta/agonists PPAR-beta/physiology Phenols/pharmacology Phenylephrine/pharmacology Gene Expression Regulation chemistry cardiovascular system Cardiology and Cardiovascular Medicine |
| Zdroj: | Cardiovascular Research, vol. 65, no. 4, pp. 832-841 CARDIOVASC RES r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu instname r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu Fundació Sant Joan de Déu |
| ISSN: | 0008-6363 |
| Popis: | OBJECTIVE: Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) is the predominant PPAR subtype in cardiac cells and plays a prominent role in the regulation of cardiac lipid metabolism. However, the role of PPARbeta/delta activators in cardiac hypertrophy is not yet known. METHODS AND RESULTS: In cultured neonatal rat cardiomyocytes, the selective PPARbeta/delta activator L-165041 (10 micromol/L) inhibited phenylephrine (PE)-induced protein synthesis ([(3)H]leucine uptake), induction of the fetal-type gene atrial natriuretic factor (ANF) and cardiac myocyte size. Induction of cardiac hypertrophy by PE stimulation also led to a reduction in the transcript levels of both muscle-type carnitine palmitoyltransferase (50%, P |
| Databáze: | OpenAIRE |
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