The ketogenic diet does not alter brain expression of orexigenic neuropeptides
| Autor: | Sylvia S. White, Patricia Szot, David Weinshenker, Kroshona D Tabb, L. Cameron Liles |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.medical_treatment Neuropeptide Galanin receptor Galanin In situ hybridization Biology Eating Mice Seizures Orexigenic Internal medicine mental disorders medicine Animals Neuropeptide Y RNA Messenger In Situ Hybridization Brain Chemistry Epilepsy 3-Hydroxybutyric Acid digestive oral and skin physiology Ketones Neuropeptide Y receptor humanities Mice Inbred C57BL Endocrinology Anticonvulsant Neurology Neurology (clinical) Energy Metabolism hormones hormone substitutes and hormone antagonists medicine.drug Ketogenic diet |
| Zdroj: | Epilepsy research. 62(1) |
| ISSN: | 0920-1211 |
| Popis: | Neuropeptide Y (NPY) and galanin are neuropeptides that are regulated by energy states and are also anticonvulsant. We tested the hypothesis that the anticonvulsant efficacy of the ketogenic diet (KD) is mediated by increased expression of NPY and galanin via alterations in food intake and energy metabolism. In situ hybridization revealed no effect of the KD on NPY or galanin mRNA expression, suggesting that increased expression of NPY and galanin do not contribute to the anticonvulsant effect of the KD. |
| Databáze: | OpenAIRE |
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