Treadmill exercise ameliorates social isolation-induced depression through neuronal generation in rat pups
| Autor: | Young Pyo Kim, Tae Beom Seo, Sam Jun Lee, Jung Wan Cho, Dae-Young Kim, Sang-Won Lee, Sun Young Jung |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Hippocampus Physical Therapy Sports Therapy and Rehabilitation Tropomyosin receptor kinase B Hippocampal formation 03 medical and health sciences 0302 clinical medicine Dorsal raphe nucleus Neurotrophic factors Neuronal generation Internal medicine Medicine Orthopedics and Sports Medicine Treadmill Social isolation business.industry Depression Dentate gyrus Tryptophan hydroxylase 030104 developmental biology Endocrinology nervous system Treadmill exercise Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Exercise Rehabilitation |
| ISSN: | 2288-1778 2288-176X |
| Popis: | Social isolation is known to induce emotional and behavioral changes in animals and humans. The effect of treadmill exercise on depression was investigated using social isolated rat pups. The rat pups in the social isolation groups were housed individually. The rat pups in the exercise groups were forced to run on treadmill for 30 min once a day from postnatal day 21 to postnatal day 34. In order to evaluate depression state of rat pups, forced swimming test was performed. Newly generated cells in the hippocampal dentate gyrus were determined by 5-bromo-2'-deoxyuridine (BrdU) immunohistochemistry. We examined the expression of 5-hydroxytryptamine (5-HT) and tryptophan hydroxylase (TPH) in the dorsal raphe using immunofluorescence. The expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) was detected by Western blot analysis. The present results demonstrated that social isolation increased resting time and decreased mobility time. Expression of 5-HT and TPH in the dorsal raphe and expression of BDNF and TrkB in the hippocampus were decreased by social isolation. The number of BrdU-positive cells in the hippocampal dentate gyrus was suppressed by social isolation. Treadmill exercise decreased resting time and increased mobility in the social isolated rat pups. Expression of 5-HT, TPH, BDNF, and TrkB was increased by treadmill exercise. The present results suggested that treadmill exercise may ameliorates social isolation-induced depression through increasing neuronal generation. |
| Databáze: | OpenAIRE |
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