Twelve-Year Survival of a Patient With Lymph Node, Pulmonary, Bone, Cardiac and Intraspinal Metastases of a Rectal Neuroendocrine Neoplasm Treated With Peptide Receptor Radionuclide Therapy—The Value of Salvage Peptide Receptor Radionuclide Therapy
| Autor: | Richard P. Baum, Jingjing Zhang, Harshad R. Kulkarni, Aviral Singh |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Lung Neoplasms Rectal Neuroendocrine Neoplasm Salvage therapy Bone Neoplasms Octreotide 030218 nuclear medicine & medical imaging Metastasis Heart Neoplasms 03 medical and health sciences 0302 clinical medicine Organometallic Compounds medicine Humans Radiology Nuclear Medicine and imaging Adverse effect Lymph node Salvage Therapy Radiotherapy Rectal Neoplasms business.industry General Medicine medicine.disease Neuroendocrine Tumors Treatment Outcome medicine.anatomical_structure Lymphatic Metastasis 030220 oncology & carcinogenesis Radionuclide therapy Toxicity Immunohistochemistry Radiology Radiopharmaceuticals business |
| Zdroj: | Clinical Nuclear Medicine. 45:e198-e200 |
| ISSN: | 1536-0229 0363-9762 |
| Popis: | We report here the 12-year survival after the first peptide receptor radionuclide therapy (PRRT) of a patient with metastatic rectal neuroendocrine neoplasms, who received 7 cycles of PRRT with Lu/Y-DOTATATE/DOTATOC in 4 treatment phases. The patient demonstrated excellent response to each cycle of treatment, without any adverse effect even after repeated PRRT cycles. Most recently, immunohistochemistry revealed a G3 neuroendocrine neoplasm and intraspinal metastasis were successfully resected by neurosurgical intervention. This case nicely demonstrates that several "salvage" PRRTs can be given over many years leading to repetitive benefit for the patient and saving patients of possible toxicity of alternative treatments. |
| Databáze: | OpenAIRE |
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