Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States

Autor: Hülya Kaya, Jill R. Stewart, Meghan F. Davis, Karen C. Carroll, Trish M. Perl, Devon Hall, Lloyd S. Miller, Maliha Aziz, Nora Pisanic, Dave C. Love, David Mohr, Jesper Larsen, Maya Nadimpalli, Lance B. Price, Carly Ordak, Christopher D. Heaney, Pranay R. Randad, Sarah M. Rhodes
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Swine
Epidemiology
lcsh:Medicine
MRSA and other staphylococci
zoonotic transmission
medicine.disease_cause
law.invention
0302 clinical medicine
Data sequences
law
AMR
030212 general & internal medicine
Animal Husbandry
bacteria
Clade
Phylogeny
Phylogenetic tree
industrial hog operations
livestock-associated diseases
pigs
Staphylococcal Infections
Antimicrobial
Anti-Bacterial Agents
food safety
Infectious Diseases
Transmission (mechanics)
Multidrug resistant bacteria
Staphylococcus aureus
Methicillin-Resistant Staphylococcus aureus
Microbiology (medical)
Livestock
030231 tropical medicine
multidrug-resistant bacteria
Biology
Microbiology
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Antibiotic resistance
North Carolina
medicine
Animals
Humans
lcsh:RC109-216
antimicrobial resistance
Research
lcsh:R
infectious disease transmission
United States
zoonoses
Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans
United States
Zdroj: Emerging Infectious Diseases, Vol 27, Iss 3, Pp 740-748 (2021)
Emerging Infectious Diseases
ISSN: 1080-6059
1080-6040
Popis: Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0–34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.
Databáze: OpenAIRE
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