Ubiquinol-10 and ubiquinone-10 levels in umbilical cord blood of healthy foetuses and the venous blood of their mothers

Autor:	Megumi Haruna, Kyouichi Sekine, Sachiyo Murashima, Etsuko Watanabe, Yoko Hasumi, Takashi Tanizaki, Masayo Matsuzaki
Rok vydání:	2010
Předmět:	Adult medicine.medical_specialty Ubiquinol Ubiquinone Umbilicus (mollusc) Mothers medicine.disease_cause Biochemistry Umbilical cord Young Adult chemistry.chemical_compound Fetus Pregnancy Internal medicine medicine Humans Chromatography High Pressure Liquid Coenzyme Q10 business.industry General Medicine Venous blood Fetal Blood Cross-Sectional Studies Endocrinology medicine.anatomical_structure chemistry Cord blood Anesthesia Female business Oxidative stress
Zdroj:	Free Radical Research. 44:1338-1344
ISSN:	1029-2470 1071-5762
DOI:	10.3109/10715762.2010.503758
Popis:	Despite their being good markers of oxidative stress for clinical use, little is known about ubiquinol-10 (reduced coenzyme Q10) and ubiquinone-10 (oxidized coenzyme Q10) levels in foetuses and their mothers. This study investigates oxidative stress in 10 healthy maternal venous, umbilical arterial and venous bloods after vaginal delivery by measuring ubiquinol-10 and ubiquinone-10 levels. Serum ubiquinol-10 and ubiquinone-10 levels were measured by HPLC with a highly sensitive electrochemical detector. Maternal venous ubiquinol-10 and ubiquinone-10 levels were significantly higher than umbilical arterial and venous levels (all p0.001). However, the ubiquinone-10/total coenzyme Q10 (CoQ10) ratio, which reflects the redox status, was significantly higher in umbilical arterial and umbilical venous blood compared to maternal venous blood (all p0.001). The ubiquinone-10/total CoQ10 ratio was higher in umbilical arterial than in umbilical venous blood (p0.01). The present study demonstrated that foetuses were under higher oxidative stress than their mothers.
Databáze:	OpenAIRE
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