High incidence of disseminated intravascular coagulation and acute cerebral infarction in acute myeloid leukemia with cup-like nuclei

Autor:	Naoki, Watanabe, Hideaki, Kitahara, Tadahiro, Honda, Hisayo, Iwasaki, Noriaki, Iwao, Norio, Komatsu, Michiaki, Koike
Rok vydání:	2022
Předmět:	Leukemia Myeloid Acute fms-Like Tyrosine Kinase 3 Incidence Mutation Acute Disease Humans Cerebral Infarction General Medicine Disseminated Intravascular Coagulation Prognosis Nucleophosmin Retrospective Studies
Zdroj:	Journal of Clinical and Experimental Hematopathology. 62:249-252
ISSN:	1880-9952 1346-4280
DOI:	10.3960/jslrt.22020
Popis:	In this study, we examined a cohort of Japanese patients with acute myeloid leukemia (AML) with cup-like nuclei. In particular, we attempted to provide a detailed definition of the clinical features of AML with cup-like nuclei. The clinical records of patients diagnosed with de novo AML were collected retrospectively. We showed that approximately 23% of all patients with AML diagnosed during the study period had AML with cup-like nuclei. All three cup-like AML cases had FLT3-ITD mutations. In addition, we reported a high incidence of disseminated intravascular coagulation and acute cerebral infarction in patients with AML with cup-like nuclei. Our results show that AML with cup-like nuclei may be more common than expected. Due to these unique characteristics, recognition of this morphology is recommended.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e333a5e210d812d6cd91b280abacab31 https://doi.org/10.3960/jslrt.22020 Zobrazit plný text záznamu