High prevalence of herpes simplex virus type 2 in acute retinal necrosis syndrome associated with herpes simplex virus in Japan
| Autor: | Tadayuki Nishide, Yumi Imai, Akiko Ogi, Nozomi Matsumura, Norihiko Itoh, Hikaru Kanai, Shigeaki Ohno |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Herpesvirus 3 Human Herpesvirus 4 Human Adolescent Herpesvirus 2 Human viruses Cytomegalovirus Eye Infections Viral Enzyme-Linked Immunosorbent Assay Herpesvirus 1 Human Antibodies Viral medicine.disease_cause Polymerase Chain Reaction Herpesviridae Virus Aqueous Humor Japan Alphaherpesvirinae Prevalence medicine Humans Herpes Genitalis Aged biology Viral culture Retinal Necrosis Syndrome Acute Middle Aged Eye infection biology.organism_classification Virology Vitreous Body Ophthalmology Herpes simplex virus DNA Viral Immunology Female |
| Zdroj: | American Journal of Ophthalmology. 129:404-405 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/s0002-9394(99)00391-8 |
| Popis: | PURPOSE: To determine the type of herpes simplex virus in acute retinal necrosis syndrome associated with herpes simplex virus. METHODS: Herpes simplex virus type 1, herpes simplex virus type 2, varicella-zoster virus, Epstein-Barr virus, and cytomegalovirus were examined by polymerase chain reaction in intraocular specimens from 16 patients with acute retinal necrosis syndrome. Anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 type-specific antibodies in serum from the patients were detected by enzyme immunoassay. RESULTS: Of 16 patients with acute retinal necrosis syndrome, seven were polymerase chain reaction positive for herpes simplex virus type 2 and nine were positive for varicella-zoster virus. Anti-herpes simplex virus type 2 antibody was positive and anti-herpes simplex virus type 1 antibody was negative in the sera of the seven patients with herpes simplex virus type 2 DNA-positive acute retinal necrosis syndrome. In contrast, anti-herpes simplex virus type 2 antibody was absent in all nine varicella-zoster virus DNA-positive acute retinal necrosis syndrome patients. CONCLUSION: Herpes simplex virus type 2 has been demonstrated to be the major causative agent in acute retinal necrosis syndrome associated with herpes simplex virus by molecular biological and serological methods. Negative preexisting anti-herpes simplex virus type 1 antibody may play an important role in acute retinal necrosis syndrome associated with herpes simplex virus type 2. |
| Databáze: | OpenAIRE |
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