Exposure to phototoxic NSAIDs and quinolones is associated with an increased risk of melanoma
| Autor: | Henk-Jan Guchelaar, Ron M. C. Herings, Loes E. Visser, Tamar Nijsten, Satu J. Siiskonen, Bruno H. Ch. Stricker, Els R. Koomen |
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| Přispěvatelé: | Epidemiology and Data Science, Dermatology, Internal Medicine |
| Rok vydání: | 2012 |
| Předmět: |
Drug
Adult Male Risk medicine.medical_specialty Quinolone Skin Neoplasms Databases Factual NSAIDs media_common.quotation_subject Population Quinolones Drug Prescriptions Phototoxicity Cohort Studies medicine Ultraviolet light Humans Pharmacology (medical) Prospective Studies Registries Risk factor Adverse effect education Melanoma media_common Aged Netherlands Skin Pharmacology education.field_of_study Carcinogenicity Chemistry Anti-Inflammatory Agents Non-Steroidal Case-control study General Medicine Odds ratio Middle Aged Dermatology Case-Control Studies Population study Female Propionates Dermatitis Phototoxic Follow-Up Studies |
| Zdroj: | Siiskonen, S J, Koomen, E R, Visser, L E, Herings, R M C, Guchelaar, H J, Stricker, B H C & Nijsten, T E C 2013, ' Exposure to phototoxic NSAIDs and quinolones is associated with an increased risk of melanoma ', European Journal of Clinical Pharmacology, vol. 69, no. 7, pp. 1437-1444 . https://doi.org/10.1007/s00228-013-1476-x European Journal of Clinical Pharmacology, 69(7), 1437-1444. Springer Verlag European Journal of Clinical Pharmacology, 69(7), 1437-1444 European Journal of Clinical Pharmacology, 69(7), 1437-1444. Springer-Verlag |
| ISSN: | 1432-1041 0031-6970 |
| Popis: | Purpose: Ultraviolet radiation exposure is the most important exogenous risk factor for cutaneous malignancies. It is possible that phototoxic drugs promote the development of cutaneous melanoma (CM) by intensifying the effect of ultraviolet light on the skin. We investigated the association between the use of common systemic phototoxic drugs and development of CM. Methods: This study was a case-control study in a Dutch population-based cohort. The drug dispensing data was obtained from PHARMO, a Dutch drug dispensing and hospital admissions registry, and linked to PALGA, the nationwide pathology network of the Netherlands. The cases were patients diagnosed with pathologically confirmed primary CM between 1991 and 2004. Controls were sampled from the PHARMO population. Exposure to systemic phototoxic drugs was measured and included antimicrobial agents, diuretics, antipsychotic drugs, antidiabetic drugs, cardiac drugs, antimalarials and nonsteroidal anti-inflammatory drugs (NSAIDs). A multivariate conditional logistic regression analysis was performed to study the association between exposure to phototoxic drugs and CM. Results: The study population included 1,318 cases and 6,786 controls. Any phototoxic drug during the study period was dispensed for 46 % of the cases and 43 % of the controls (p = 0.012). The use of quinolones [odds ratio (OR) 1.33, 95 % confidence interval (CI) 1.01-1.76] and propionic acid derivative NSAIDs (OR 1.33, 95 % CI 1.14-1.54) had a positive association with CM. Conclusions: Our study shows that the use of phototoxic drugs is associated with an increased risk of developing CM. Even a short-term use of phototoxic quinolones and propionic acid derivative NSAIDs may increase the risk for CM. Patient education to promote sun-protective behaviour is essential to avoid immediate adverse effects and possible long-term effects of phototoxic drugs. |
| Databáze: | OpenAIRE |
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