Socio-economic Parameters and Mortality in Turner Syndrome
| Autor: | Svend Juul, Britta E Hjerrild, Claus Højbjerg Gravholt, Kristian H. Mortensen, Kirstine Stochholm, Morten Frydenberg |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Employment Gerontology medicine.medical_specialty Denmark Endocrinology Diabetes and Metabolism Population Mothers Turner Syndrome Kaplan-Meier Estimate Endocrinology Quality of life Internal medicine Turner syndrome Odds Ratio Humans Medicine Registries education Socioeconomic status Aged Proportional Hazards Models Retirement education.field_of_study Marital Status business.industry Proportional hazards model Ovary Hazard ratio Age Factors Confounding Factors Epidemiologic General Medicine Odds ratio Middle Aged medicine.disease Body Height Logistic Models Socioeconomic Factors Income Educational Status Marital status Female business Infertility Female Demography |
| Zdroj: | Krag, K S, Hjerrild, B, Mortensen, K H, Juul, S, Frydenberg, M & Gravholt, C H 2012, ' Socio-economic Parameters and Mortality in Turner Syndrome ', European Journal of Endocrinology . https://doi.org/10.1530/EJE-11-1066 |
| Popis: | BackgroundTurner syndrome (TS) is characterized by hypogonadism, short adult height, increased morbidity and mortality, contrasted by self-reported normal quality of life and perception of health. Small studies have indicated a similar level of education compared with the background population.AimTo study the socioeconomic profile in TS and the impact of these factors on mortality.Materials and methodsRegister study using Danish nationwide registries. Nine hundred and seventy-nine TS females and 94 850 controls were included. Information concerning cohabitation, motherhoods, level of education (bachelor degree), income, retirement, and death were obtained. One hundred and three TS and 5989 controls died during the study period. For the socioeconomic parameters, median age at first relevant episode was calculated. Income was analyzed using conditional logistic regression and the other parameters using Cox regression.ResultsIn comparison with controls, TS had significantly fewer partnerships (hazard ratio (HR): 0.45), fewer motherhoods (HR: 0.18), and retired earlier (HR: 1.8). After the diagnosis of TS, the risk of retiring was increased. Educational attainment (HR: 1.0) as well as risk of unemployment was similar. Before the age of 30, low income was significantly more frequent; hereafter, it was similar to controls. Mortality was significantly increased (HR: 2.9) and slightly lower after adjustment for cohabitation and education (HR: 2.7).ConclusionsA divergent socioeconomic profile is apparent, with a reduced proportion of TS persons finding a partner and becoming mothers. The educational level was similar to controls. The increased mortality in TS was not materially affected after adjustment for cohabitation and education. |
| Databáze: | OpenAIRE |
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