Assessment of Corticosteroid-induced Osteonecrosis in Children Undergoing Chemotherapy for Acute Lymphoblastic Leukemia
| Autor: | Atsushi Kikuta, Nobuyuki Hyakuna, Yasuo Horikoshi, Yasuhiro Okamoto, Yasuto Shimomura, Kazuhiro Kogawa, Masahito Tsurusawa, Takeji Matsushita, Arata Watanabe, Chihiro Kawakami, Takashi Taga, Tsuyako Iwai, Keiko Asami |
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| Rok vydání: | 2014 |
| Předmět: |
Male
corticosteroid medicine.medical_specialty Adolescent Prednisolone dexamethasone acute lymphoblastic leukemia Asian People Adrenal Cortex Hormones Risk Factors Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Cumulative incidence Child Childhood Acute Lymphoblastic Leukemia Dexamethasone Retrospective Studies business.industry Incidence Incidence (epidemiology) osteonecrosis Infant Cancer Retrospective cohort study Original Articles Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Surgery Leukemia Oncology Child Preschool Pediatrics Perinatology and Child Health ComputingMethodologies_DOCUMENTANDTEXTPROCESSING Female business medicine.drug |
| Zdroj: | Journal of Pediatric Hematology/Oncology |
| ISSN: | 1077-4114 |
| Popis: | Supplemental Digital Content is available in the text. Steroid-induced osteonecrosis (ON) is a challenging complication encountered during modern chemotherapy for childhood acute lymphoblastic leukemia (ALL). We retrospectively assessed the incidence of ON and its risk factors in a total of 1095 patients enrolled in 3 consecutive Japanese Children’s Cancer and Leukemia Study Group ALL studies (ALL941 [1994 to 2000], n=464; ALL2000 [2000 to 2004], n=305; and ALL2004 [2004 to 2010], n=326). ON was diagnosed in 16 patients, of whom 15 were symptomatic. The cumulative incidence of ON was 0.76% in ALL941, 0.35% in ALL2000, and 3.6% in ALL2004. The incidence of ON in ALL941/2000, in which only prednisolone was administered as a steroid, was significantly lower than that in ALL2004, in which dexamethasone was used as a partial substitute for prednisolone (P |
| Databáze: | OpenAIRE |
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