Biochemical and structural changes in rat liver resulting from the parenteral administration of a large dose of sodium salicylate
| Autor: | T. F. Slater, G.R. Bullock, B. C. Sawyer, V. B. Delaney |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
medicine.medical_specialty
Urate Oxidase Sodium Salicylate Sodium Acid Phosphatase chemistry.chemical_element In Vitro Techniques Sodium Chloride Endoplasmic Reticulum Biochemistry chemistry.chemical_compound Internal medicine medicine Animals Bile Sodium salicylate Glucuronidase Adenosine Triphosphatases Pharmacology chemistry.chemical_classification biology Proadifen Endoplasmic reticulum Acid phosphatase Alanine Transaminase Catalase Malonates Enzymes Rats Microscopy Electron Endocrinology Enzyme Liver chemistry Alanine transaminase Microsomes Liver Microsome biology.protein Cytochromes Female Injections Intraperitoneal Protein Binding |
| Zdroj: | Biochemical Pharmacology. 19:245-253 |
| ISSN: | 0006-2952 |
| Popis: | The effects of a large parenteral dose of sodium salicylate on rat liver and plasma enzymes have been studied. A dose of 400 mg/kg by i.p. injection did not result in significant elevation of three plasma enzymes investigated: β-glucuronidase, acid phosphatase and alanine aminotransferase. There was, however, a rapid decrease in the liver's concentration of NADPH 2 and a similarly rapid choleresis. Although the total concentration of ATP in the liver was not altered by salicylate dosing the distribution between the large particle fraction and the cell sap was changed in favour of there being relatively more ATP in the cell sap fraction. Sodium salicylate produced only a small change in the microsomal cytochrome P 450 spectrum in vitro in comparison with the effects found with the drug SKF 525A that is known to bind strongly to P 450 . Liver sections obtained from rats dosed 1–3 hr previously with salicylate appeared relatively normal when examined by light microscopy. Electron microscopy, however, demonstrated several early effects of salicylate on liver parenchyma: there appeared to be an early increase in the number of peroxisomes, and multivesicular bodies were in evidence around the Golgi zone. The endoplasmic reticulum and attached ribosomes exhibited a normal appearance. These effects of salicylate on rat liver are discussed and contrasted with the results found previously with known hepatotoxic agents. |
| Databáze: | OpenAIRE |
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