DPEP1 expression promotes proliferation and survival of leukaemia cells and correlates with relapse in adults with common B cell acute lymphoblastic leukaemia
| Autor: | Li-Xin Wu, Xiao-Hui Zhang, Hao Jiang, Jia-Min Zhang, Kai-Yan Liu, Guo-Rui Ruan, Lan-Ping Xu, Ya-Zhen Qin, Qian Jiang, Jing Zhang, Yonghuai Feng, Yu-Hong Chen, Xiao-Jun Huang, Yu Wang, Yan Xu, Yan-Rong Liu, Robert Peter Gale, Bin Jiang |
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| Rok vydání: | 2020 |
| Předmět: |
Male
Dipeptidases Mice Nude GPI-Linked Proteins Clinical correlation Mice 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Animals Humans Medicine Cumulative incidence B cell Cell Proliferation Metalloproteinase business.industry Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.anatomical_structure 030220 oncology & carcinogenesis B-cell acute lymphoblastic leukaemia Cancer research Female Neoplasm Recurrence Local business 030215 immunology |
| Zdroj: | British Journal of Haematology. 190:67-78 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.16505 |
| Popis: | Dehydropeptidase-1 (DPEP1) is a zinc-dependent metalloproteinase abnormally expressed in many cancers. However, its potential role in adults with B cell acute lymphoblastic leukaemia (ALL) is unknown. We found that in adults with common B cell ALL high DPEP1, transcript levels at diagnosis were independently associated with an increased cumulative incidence of relapse (CIR) and worse relapse-free survival (RFS) compared with subjects with low transcript levels. We show an increased proliferation and prosurvival role of DPEP1 in B cell ALL cells via regulation of phosphCREB and p53, which may be the biological basis of the clinical correlation we report. Our data implicate DPEP1 expression in the biology of common B cell ALL in adults. We report clinical correlates and provide a potential biological basis for these correlations. If confirmed, analysing DPEP1 transcript levels at diagnosis could help predict therapy outcomes. Moreover, regulation of DPEP1 expression could be a therapy target in B cell ALL. |
| Databáze: | OpenAIRE |
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